Hutchison R Matthew, Culham Jody C, Flanagan J Randall, Everling Stefan, Gallivan Jason P
Department of Psychology, Harvard University, Cambridge, MA, USA; Center for Brain Science, Harvard University, Cambridge, MA, USA; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.
Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada; Department of Psychology, University of Western Ontario, London, Ontario, Canada.
Neuroimage. 2015 Aug 1;116:10-29. doi: 10.1016/j.neuroimage.2015.04.068. Epub 2015 May 10.
Based on its diverse and wide-spread patterns of connectivity, primate posteromedial cortex (PMC) is well positioned to support roles in several aspects of sensory-, cognitive- and motor-related processing. Previous work in both humans and non-human primates (NHPs) using resting-state functional MRI (rs-fMRI) suggests that a subregion of PMC, the medial parieto-occipital cortex (mPOC), by virtue of its intrinsic functional connectivity (FC) with visual cortex, may only play a role in higher-order visual processing. Recent neuroanatomical tracer studies in NHPs, however, demonstrate that mPOC also has prominent cortico-cortical connections with several frontoparietal structures involved in movement planning and control, a finding consistent with increasing observations of reach- and grasp-related activity in the mPOC of both NHPs and humans. To reconcile these observations, here we used rs-fMRI data collected from both awake humans and anesthetized macaque monkeys to more closely examine and compare parcellations of mPOC across species and explore the FC patterns associated with these subdivisions. Seed-based and voxel-wise hierarchical cluster analyses revealed four broad spatially separated functional boundaries that correspond with graded differences in whole-brain FC patterns in each species. The patterns of FC observed are consistent with mPOC forming a critical hub of networks involved in action planning and control, spatial navigation, and working memory. In addition, our comparison between species indicates that while there are several similarities, there may be some species-specific differences in functional neural organization. These findings and the associated theoretical implications are discussed.
基于其多样且广泛分布的连接模式，灵长类动物的后内侧皮层（PMC）在支持感觉、认知和运动相关处理的多个方面发挥作用方面具有良好的条件。先前在人类和非人类灵长类动物（NHPs）中使用静息态功能磁共振成像（rs-fMRI）的研究表明，PMC的一个子区域，即内侧顶枕皮层（mPOC），由于其与视觉皮层的内在功能连接（FC），可能仅在高阶视觉处理中发挥作用。然而，最近在NHPs中的神经解剖示踪研究表明，mPOC还与几个参与运动计划和控制的额顶叶结构有显著的皮质-皮质连接，这一发现与在NHPs和人类的mPOC中越来越多观察到的与伸手和抓握相关的活动一致。为了协调这些观察结果，我们在这里使用了从清醒人类和麻醉猕猴收集的rs-fMRI数据，以更仔细地检查和比较跨物种的mPOC分区，并探索与这些细分相关的FC模式。基于种子点和体素的层次聚类分析揭示了四个广泛的空间分离的功能边界，这些边界与每个物种全脑FC模式的分级差异相对应。观察到的FC模式与mPOC形成参与动作计划和控制、空间导航和工作记忆的网络的关键枢纽一致。此外，我们的物种间比较表明，虽然有一些相似之处，但在功能神经组织方面可能存在一些物种特异性差异。本文讨论了这些发现及其相关的理论意义。
