Kolesnikova L L, Madaeva L M, Semenova N V, Solodova E I, Grebenkina L A, Darenskaya M A
Vestn Ross Akad Med Nauk. 2014(11-12):11-6. doi: 10.15690/vramn.v69i11-12.1177.
Our aim was to assess lipid peroxidation - antioxidant protection with the definition of the oxidative stress coefficient in perimenopausal women with sleep disorders.
45 perimenopausal women (mean age 49.1±0.32) were examined: 26 patients with sleep disorders, 19 - without sleep disorders. Evaluation of sleep disorders was conducted using a questionnaire of Stanford Centre for the Study of Sleep, test for assessment subjective severity of insomnia, the questionnaire for the quantitative assessment of the risks of sleep apnea, the scale for quantifying the degree of daytime sleepiness Epworth. We used spectrophotometric methods for lipid peroxidation - antioxidant system investigation. Statistical analysis was performed by non-parametric tests.
In perimenopausal women sleep disorders often presents falling asleep difficulties (93.3%) and morning awakening difficulties (78.8%). Complaints of snoring detected in 33.3% of patients. Insomnia severity index was 21.3±0.54, the total score on the Epworth scale - 12.2±0.42. The study results showed increase of secondary products of lipid peroxidation (ketodienes and coupled trienes) levels by 2.2 times (p <0.05). Coefficient oxidative stress in women with sleep disorders is higher by 2 times than in group without sleep disorders.
In perimenopausal women sleep disorders are associated with oxidative stress, which is pathogenic rationale for inclusion in the complex therapy of these patients drugs that inhibit of lipid peroxidation activation.
我们的目的是通过定义围绝经期睡眠障碍女性的氧化应激系数来评估脂质过氧化 - 抗氧化保护作用。
对45名围绝经期女性（平均年龄49.1±0.32岁）进行了检查：26名患有睡眠障碍，19名没有睡眠障碍。使用斯坦福睡眠研究中心的问卷、失眠主观严重程度评估测试、睡眠呼吸暂停风险定量评估问卷、爱泼华兹日间嗜睡程度量化量表对睡眠障碍进行评估。我们使用分光光度法研究脂质过氧化 - 抗氧化系统。采用非参数检验进行统计分析。
围绝经期睡眠障碍女性常出现入睡困难（93.3%）和早醒困难（78.8%）。33.3%的患者有打鼾主诉。失眠严重程度指数为21.3±0.54，爱泼华兹量表总分 - 12.2±0.42。研究结果显示脂质过氧化二级产物（酮二烯和共轭三烯）水平增加了2.2倍（p<0.05）。睡眠障碍女性的氧化应激系数比无睡眠障碍组高2倍。
围绝经期睡眠障碍与氧化应激有关，这是在这些患者的综合治疗中加入抑制脂质过氧化激活药物的病理依据。
