Semenova N V, Madaeva I M, Kolesnikova L I
Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(7):7-13. doi: 10.17116/jnevro20191190717.
To determine the ethnic features of the functioning of the 'lipid peroxidation-antioxidants' system and to evaluate the role of melatonin as one of the antioxidant defense system components in Caucasian and Asian perimenopausal women with insomnia.
One hundred and ten perimenopausal women divided into Caucasian (Russian ethnic group (n=60)) and Asian (Buryat ethnic group (n=50)) were studied. All women underwent clinical-anamnestic examination. Diagnoses of insomnia and obstructive sleep apnea syndrome (OSAS) were made according to the results of specialized somnological questionnaires and polysomnographic monitoring. A multidimensional discriminant analysis was used to reveal the most informative parameters among the hormonal and metabolic parameters studied (melatonin 06.00-07.00h; 12.00-13.00h; 18.00-19.00h; 23.00-00.00h; lipid profile, lipid peroxidation and antioxidant defense system).
The most informative indicators of the metabolic system in Caucasians with insomnia are morning, evening, night melatonin, ketodienes and conjugated trienes, oxidized glutathione (GSSG); with insomnia and OSAS: morning, day, night melatonin, substrates with conjugated double bonds, total cholesterol; in Asian women with insomnia: evening, night melatonin, superoxide dismutase activity (SOD), diene conjugates, active products of thiobarbituric acid, cholesterol of very low density lipoproteins; in women with insomnia and OSAS: morning, day melatonin, SOD, GSSG. The recalculation of the informativeness of each attribute as a percentage showed the prevalence of the influence of the antioxidant protection system parameters over those of lipid peroxidation processes. The contribution of melatonin to the total share of the antioxidant protection system components is more than 60%.
Both in Caucasian and Asian women with sleep disorders, there is stress in the antioxidant defense system, where melatonin is the largest contributor.
确定“脂质过氧化-抗氧化剂”系统功能的种族特征，并评估褪黑素作为抗氧化防御系统组成部分之一，在患有失眠症的白种人和亚洲围绝经期女性中的作用。
研究了110名围绝经期女性，分为白种人（俄罗斯族（n = 60））和亚洲人（布里亚特族（n = 50））。所有女性均接受了临床-病史检查。根据专业睡眠学问卷和多导睡眠图监测结果，诊断失眠和阻塞性睡眠呼吸暂停综合征（OSAS）。采用多维判别分析，在研究的激素和代谢参数（06:00 - 07:00h、12:00 - 13:00h、18:00 - 19:00h、23:00 - 00:00h的褪黑素；血脂谱、脂质过氧化和抗氧化防御系统）中，找出最具信息量的参数。
患有失眠症的白种人代谢系统中，最具信息量的指标是早晨、傍晚、夜间的褪黑素、酮二烯和共轭三烯、氧化型谷胱甘肽（GSSG）；患有失眠症和OSAS的白种人：早晨、白天、夜间的褪黑素、具有共轭双键的底物、总胆固醇；患有失眠症的亚洲女性：傍晚、夜间的褪黑素、超氧化物歧化酶活性（SOD）、二烯共轭物、硫代巴比妥酸活性产物、极低密度脂蛋白胆固醇；患有失眠症和OSAS的亚洲女性：早晨、白天的褪黑素、SOD、GSSG。将每个属性的信息量重新计算为百分比后发现，抗氧化保护系统参数的影响普遍高于脂质过氧化过程的参数。褪黑素在抗氧化保护系统组成部分的总占比中贡献超过60%。
在患有睡眠障碍的白种人和亚洲女性中，抗氧化防御系统均存在应激，其中褪黑素的贡献最大。
