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大鼠α1-酸性糖蛋白不同糖基化形式分泌速率的变化

Variations in the rate of secretion of different glycosylated forms of rat alpha 1-acid glycoprotein.

作者信息

Drechou A, Rouzeau J D, Feger J, Durand G

机构信息

Laboratoire de Biochimie-URA CNRS 622, UFR des Sciences Pharmaceutiques et Biologiques, Châtenay-Malabry, France.

出版信息

Biochem J. 1989 Nov 1;263(3):961-4. doi: 10.1042/bj2630961.

DOI:10.1042/bj2630961
PMID:2597138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1133524/
Abstract

Various studies have shown that oligosaccharides play an important role in the intracellular transport and secretion of glycoproteins. We show here a difference in the rate of secretion of two mature glycoforms of a single protein, alpha 1-acid glycoprotein. This indicates the existence of kinetically different pathways for these two forms for transport from the medial Golgi to the extracellular medium.

摘要

多项研究表明，寡糖在糖蛋白的细胞内运输和分泌过程中发挥着重要作用。我们在此展示了单一蛋白α1-酸性糖蛋白的两种成熟糖型的分泌速率存在差异。这表明这两种糖型从高尔基体中间膜囊运输至细胞外介质的过程存在动力学上不同的途径。

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Variations in the rate of secretion of different glycosylated forms of rat alpha 1-acid glycoprotein.大鼠α1-酸性糖蛋白不同糖基化形式分泌速率的变化
Biochem J. 1989 Nov 1;263(3):961-4. doi: 10.1042/bj2630961.
2
Differential secretion of alpha 1-acid glycoprotein occurs in the Golgi complex of isolated rat hepatocytes. Evidence of partial retention in the Golgi.α1-酸性糖蛋白的差异分泌发生在分离的大鼠肝细胞的高尔基体中。存在部分保留在高尔基体中的证据。
Eur J Biochem. 1994 Feb 1;219(3):1073-9. doi: 10.1111/j.1432-1033.1994.tb18590.x.
3
Effect of the threonine analog beta-hydroxynorvaline on the glycosylation and secretion of alpha 1-acid glycoprotein by rat hepatocytes.
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Increased affinity to concanavalin A and enhanced secretion of alpha 1-acid glycoprotein by hepatocytes isolated from turpentine-treated rats.从松节油处理的大鼠分离出的肝细胞对刀豆球蛋白A的亲和力增加，且α1-酸性糖蛋白分泌增强。
Eur J Cell Biol. 1989 Oct;50(1):111-6.
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Eur J Biochem. 1987 Jan 2;162(1):83-8. doi: 10.1111/j.1432-1033.1987.tb10545.x.
6
Differential rates of glycoprotein secretion by isolated rat hepatocytes studied in terms of concanavalin A binding.根据伴刀豆球蛋白A结合情况研究分离的大鼠肝细胞的糖蛋白分泌差异率。
Eur J Biochem. 1992 Jan 15;203(1-2):277-83. doi: 10.1111/j.1432-1033.1992.tb19857.x.
7
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引用本文的文献

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Alpha 1-acid glycoprotein (orosomucoid): pathophysiological changes in glycosylation in relation to its function.α1-酸性糖蛋白（类粘蛋白）：与功能相关的糖基化病理生理变化
Glycoconj J. 1995 Jun;12(3):227-33. doi: 10.1007/BF00731324.
2
Changes in serum glycoprotein glycosylation during experimental inflammation in mice are general, unrelated to protein type, and opposite changes in man and rat: studies on mouse serum alpha 1-acid glycoprotein, alpha 1-esterase, and alpha 1-protease inhibitor.小鼠实验性炎症期间血清糖蛋白糖基化的变化具有普遍性，与蛋白质类型无关，且在人和大鼠中变化相反：对小鼠血清α1-酸性糖蛋白、α1-酯酶和α1-蛋白酶抑制剂的研究。
Inflammation. 1992 Dec;16(6):631-44. doi: 10.1007/BF00919346.

本文引用的文献

1
Evidence for alpha-1-acid glycoprotein populations of different pI values after concanavalin A affinity chromatography. Study of their evolution during inflammation in man.伴刀豆球蛋白A亲和层析后不同等电点α-1-酸性糖蛋白群体的证据。对其在人类炎症过程中演变的研究。
Biochim Biophys Acta. 1981 Apr 28;668(2):235-45. doi: 10.1016/0005-2795(81)90031-3.
2
Changes in the blood level and affinity to concanavalin A of rat plasma glycoproteins during acute inflammation and hepatoma growth.大鼠急性炎症和肝癌生长过程中血浆糖蛋白的血药浓度变化及其对伴刀豆球蛋白A的亲和力
Biochem J. 1982 Sep 15;206(3):545-53. doi: 10.1042/bj2060545.
3
The acute phase response of plasma protein synthesis during experimental inflammation.实验性炎症期间血浆蛋白合成的急性期反应。
J Biol Chem. 1982 Sep 10;257(17):10271-7.
4
Hepatoma secretory proteins migrate from rough endoplasmic reticulum to Golgi at characteristic rates.肝癌分泌蛋白以特定速率从糙面内质网迁移至高尔基体。
Nature. 1983;304(5921):80-3. doi: 10.1038/304080a0.
5
An immunochemical procedure to evaluate the degree of desialylation of alpha 1-acid glycoprotein in rat serum.一种评估大鼠血清中α1-酸性糖蛋白去唾液酸化程度的免疫化学方法。
J Immunol Methods. 1984 Nov 30;74(2):267-71. doi: 10.1016/0022-1759(84)90293-x.
6
Intracellular transport of secretory and membrane proteins in hepatoma cells infected by vesicular stomatitis virus.水泡性口炎病毒感染的肝癌细胞中分泌蛋白和膜蛋白的细胞内运输
Cell. 1980 Dec;22(3):709-17. doi: 10.1016/0092-8674(80)90547-4.
7
[Isolated hepatocytes fixed on collagen, an accurate model for the the secretion of proteins in a minimal medium. Response to inflammation].固定在胶原蛋白上的分离肝细胞，是在基础培养基中分泌蛋白质的精确模型。对炎症的反应
Biol Cell. 1983;48(2-3):203-6. doi: 10.1111/j.1768-322x.1984.tb00213.x.
8
Kinetics of serum protein secretion by cultured hepatoma cells. Evidence for multiple secretory pathways.
J Biol Chem. 1983 Mar 10;258(5):3304-8.
9
The acute-phase response of cultured rat hepatocytes. System characterization and the effect of human cytokines.培养大鼠肝细胞的急性期反应。系统特征及人细胞因子的作用。
Biochem J. 1984 Dec 1;224(2):505-14. doi: 10.1042/bj2240505.
10
High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.大鼠肝脏实质细胞分离的高效制备：生化与精细结构研究
J Cell Biol. 1969 Dec;43(3):506-20. doi: 10.1083/jcb.43.3.506.