Becker Christoph A, Schmälzle Ralf, Flaisch Tobias, Renner Britta, Schupp Harald T
Department of Psychology, University of Konstanz, Germany
Department of Psychology, University of Konstanz, Germany.
Soc Cogn Affect Neurosci. 2015 Dec;10(12):1722-9. doi: 10.1093/scan/nsv063. Epub 2015 May 13.
Depletion imposes both need and desire to drink, and potentiates the response to need-relevant cues in the environment. The present fMRI study aimed to determine which neural structures selectively increase the incentive value of need-relevant stimuli in a thirst state. Towards this end, participants were scanned twice--either in a thirst or no-thirst state--while viewing pictures of beverages and chairs. As expected, thirst led to a selective increase in self-reported pleasantness and arousal by beverages. Increased responses to beverage when compared with chair stimuli were observed in the cingulate cortex, insular cortex and the amygdala in the thirst state, which were absent in the no-thirst condition. Enhancing the incentive value of need-relevant cues in a thirst state is a key mechanism for motivating drinking behavior. Overall, distributed regions of the motive circuitry, which are also implicated in salience processing, craving and interoception, provide a dynamic body-state dependent representation of stimulus value.
缺水会引发饮水的需求和欲望，并增强对环境中与需求相关线索的反应。本功能磁共振成像（fMRI）研究旨在确定在口渴状态下哪些神经结构会选择性地增加与需求相关刺激的激励价值。为此，参与者在口渴或不口渴状态下分别接受了两次扫描，同时观看饮料和椅子的图片。正如预期的那样，口渴导致参与者自我报告对饮料的愉悦感和兴奋感选择性增加。与不口渴状态相比，在口渴状态下，扣带回皮质、岛叶皮质和杏仁核中观察到对饮料刺激的反应增强，而在不口渴状态下则没有这种反应。增强口渴状态下与需求相关线索的激励价值是激发饮水行为的关键机制。总体而言，动机回路的分布区域，也与显著性处理、渴望和内感受有关，提供了一种依赖于身体状态的动态刺激价值表征。
