From the 1 Department of Clinical Microbiology, Karolinska University Hospital , Stockholm , Sweden.
Infect Dis (Lond). 2015;47(10):734-8. doi: 10.3109/23744235.2015.1047402. Epub 2015 May 14.
In 2014, an outbreak of enterovirus D68 (EV-D68) was observed in North America, with cases of severe respiratory illness and a possible etiological link to cases of acute flaccid paralysis. EV-D68 has also been reported from European countries, but no data from Sweden are available. This study investigated respiratory specimens collected during July-October 2014 from 30 Swedish children aged 0-9 years who were positive for enterovirus and/or rhinovirus in routine clinical PCR. Seven samples were typed as EV-D68 by VP4/VP2 sequencing. Two genetically distinct EV-D68 variants coexisted. Six viruses belonged to clade B, the variant involved in the North American outbreak, and one virus belonged to clade A. Respiratory illness was the major symptom among EV-D68 infected patients and all fully recovered. This is the first report of EV-D68 in Sweden. Considering the current epidemiological situation, genotyping and specific EV-D68 testing should be considered in patients with severe respiratory illness who test positive for enterovirus or rhinovirus in routine diagnostics.
2014 年，北美观察到肠病毒 D68（EV-D68）爆发，出现严重呼吸道疾病病例，可能与急性弛缓性麻痹病例有关。EV-D68 也已在欧洲国家报告，但瑞典尚无相关数据。本研究调查了 2014 年 7 月至 10 月期间采集的 30 份瑞典儿童（0-9 岁）呼吸道标本，这些儿童在常规临床 PCR 中对肠道病毒和/或鼻病毒呈阳性。通过 VP4/VP2 测序，7 个样本被确定为 EV-D68。两种遗传上不同的 EV-D68 变体同时存在。6 种病毒属于 B 组，与北美爆发相关的变体，1 种病毒属于 A 组。呼吸道疾病是 EV-D68 感染患者的主要症状，所有患者均完全康复。这是瑞典首例 EV-D68 报告。鉴于当前的流行病学情况，对于在常规诊断中对肠道病毒或鼻病毒呈阳性的严重呼吸道疾病患者，应考虑进行基因分型和特定的 EV-D68 检测。
