Department of HIV/AIDS, World Health Organization, Geneva, Switzerland.
FHI 360, Accra, Ghana.
Clin Infect Dis. 2015 Jun 1;60 Suppl 3:S191-5. doi: 10.1093/cid/civ070.
The 2014 World Health Organization guidelines for human immunodeficiency virus postexposure prophylaxis (PEP) are the first to combine recommendations for all populations and exposures. To inform the development of these guidelines, we gathered views of end users on key aspects of PEP provision. A mixed-methods approach was used to gather views from the populations for whom the guideline will be of relevance. Data gathered from an online survey, focus group discussions, and previously collected data from in-depth interviews with key populations were used to inform the development of recommendations, in particular where there is a paucity of evidence to assess the benefits and harms of an intervention. This was a successful method to gather end users' views and preferences; however, limitations exist in the generalizability and reliability of the evidence. Future guideline development processes should consider methods to include the views of end users to guide the decision-making process.
2014 年世界卫生组织（世卫组织）艾滋病毒暴露后预防（PEP）指南是首次为所有人群和暴露情况合并提出建议。为了为制定这些指南提供信息，我们征求了终端用户对 PEP 提供的关键方面的意见。采用混合方法从将从相关的目标人群中征求意见。从在线调查、焦点小组讨论和之前对关键人群进行的深入访谈中收集的数据被用来为建议的制定提供信息，尤其是在评估干预措施的益处和危害方面证据不足的情况下。这是一个成功的方法，可以收集终端用户的意见和偏好；但是，证据的普遍性和可靠性存在局限性。未来的指南制定过程应考虑采用纳入终端用户意见的方法，以指导决策过程。
