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人类免疫缺陷病毒与艾滋病的预防：暴露后预防（包括医护人员）

Prevention of human immunodeficiency virus and AIDS: postexposure prophylaxis (including health care workers).

作者信息

Beekmann Susan E, Henderson David K

机构信息

Department of Internal Medicine, The University of Iowa College of Medicine, Infectious Diseases SW34-J GH, Iowa City, IA 52242, USA.

Clinical Center, National Institutes of Health, Bethesda, Building 10-CRC, Rm 6-2551, MD 20892, USA.

出版信息

Infect Dis Clin North Am. 2014 Dec;28(4):601-13. doi: 10.1016/j.idc.2014.08.005. Epub 2014 Oct 5.

DOI:10.1016/j.idc.2014.08.005
PMID:25287589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4253549/
Abstract

Postexposure prophylaxis (PEP), which is designed to prevent human immunodeficiency virus (HIV) infection after an exposure, is one of several strategies for HIV prevention. PEP was first used after occupational HIV exposures in the late 1980s, with the Centers for Disease Control and Prevention issuing the first set of guidelines that included considerations regarding the use of antiretroviral agents for PEP after occupational HIV exposures in 1990. Use of PEP has been extended to nonoccupational exposures, including after sexual contact or injection-drug use. This article provides a rationale for PEP, assessment of the need for PEP, and details of its implementation.

摘要

暴露后预防（PEP）旨在预防暴露后感染人类免疫缺陷病毒（HIV），是多种HIV预防策略之一。PEP最早于20世纪80年代末用于职业性HIV暴露后预防，疾病控制与预防中心于1990年发布了第一套指南，其中包括关于职业性HIV暴露后使用抗逆转录病毒药物进行PEP的相关考量。PEP的使用已扩展到非职业性暴露，包括性接触或注射吸毒后。本文阐述了PEP的基本原理、PEP需求评估及其实施细节。

相似文献

[1]
Prevention of human immunodeficiency virus and AIDS: postexposure prophylaxis (including health care workers).

Infect Dis Clin North Am. 2014-12

[2]
Human immunodeficiency virus postexposure prophylaxis for adolescents and children.

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[3]
Public Health Service guidelines for the management of health-care worker exposures to HIV and recommendations for postexposure prophylaxis. Centers for Disease Control and Prevention.

MMWR Recomm Rep. 1998-5-15

[4]
Updated US Public Health Service guidelines for the management of occupational exposures to human immunodeficiency virus and recommendations for postexposure prophylaxis.

Infect Control Hosp Epidemiol. 2013-9

[5]
Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis.

MMWR Recomm Rep. 2001-6-29

[6]
[HIV post exposure prophylaxis therapy - the experience of two major AIDS centers].

Harefuah. 2013-4

[7]
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J Fam Pract. 2006-7

[8]
Use of HIV Postexposure Prophylaxis in healthcare workers after occupational exposure: a Thai university hospital setting.

J Med Assoc Thai. 2006-7

[9]
The Danish PEP Registry: Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012.

Infect Dis (Lond). 2015-11-3

[10]
Evaluation of HIV postexposure prophylaxis for occupational and nonoccupational exposures at a deployed U.S. military trauma hospital.

Mil Med. 2012-12

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[2]
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J Int AIDS Soc. 2025-6

[3]
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Acad Pathol. 2024-8-1

[4]
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Int Health. 2024-3-4

[5]
Healthcare practitioners and students' PEP knowledge, attitude and adherence in Southern Africa.

Health SA. 2022-11-9

[6]
Drug users' awareness of and willingness to use HIV non-occupational post-exposure prophylaxis (nPEP) services in China: a mixed methods study.

BMC Infect Dis. 2022-2-14

[7]
Clinical Outcomes of Post-exposure Prophylaxis following Occupational Exposure to Human Immunodeficiency Virus at Dental Departments of Hiroshima University Hospital.

Curr HIV Res. 2020

[8]
Occupational Health Update: Focus on Preventing the Acquisition of Infections with Pre-exposure Prophylaxis and Postexposure Prophylaxis.

Infect Dis Clin North Am. 2016-9

[9]
Update on the Epidemiology and Prevention of HIV/AIDS in the United States.

Curr Epidemiol Rep. 2015-6

本文引用的文献

[1]
Likely female-to-female sexual transmission of HIV--Texas, 2012.

MMWR Morb Mortal Wkly Rep. 2014-3-14

[2]
High-risk Sexual Behavior is Associated with Post-Exposure Prophylaxis Non-adherence among Men who have Sex with Men Enrolled in a Combination Prevention Intervention.

J Sex Transm Dis. 2013

[3]
Reply to Tan et al.

Infect Control Hosp Epidemiol. 2014-3

[4]
Incidence of transmitted antiretroviral drug resistance in treatment-naive HIV-1-infected persons in a large South Central United States clinic.

Ann Pharmacother. 2014-4

[5]
HIV Drug Resistance: Problems and Perspectives.

Infect Dis Rep. 2013-6-6

[6]
A multicenter study of initiation of antiretroviral therapy and transmitted drug resistance in antiretroviral-naive adolescents and young adults with HIV in New York City.

Clin Infect Dis. 2014-3

[7]
Community HIV-1 drug resistance is associated with transmitted drug resistance.

HIV Med. 2014-7

[8]
Nonoccupational postexposure HIV prophylaxis in sexual assault programs: a survey of SANE and FNE program coordinators.

J Assoc Nurses AIDS Care. 2013-10-5

[9]
The prevalence of transmitted resistance to first-generation non-nucleoside reverse transcriptase inhibitors and its potential economic impact in HIV-infected patients.

PLoS One. 2013-8-22

[10]
Updated US Public Health Service guidelines for the management of occupational exposures to human immunodeficiency virus and recommendations for postexposure prophylaxis.

Infect Control Hosp Epidemiol. 2013-9

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