背水一战：2014 - 2015年埃博拉病毒爆发期间采用的新策略与现有策略
Backs against the wall: novel and existing strategies used during the 2014-2015 Ebola virus outbreak.
作者信息
Wong Gary, Kobinger Gary P
机构信息
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
出版信息
Clin Microbiol Rev. 2015 Jul;28(3):593-601. doi: 10.1128/CMR.00014-15.
The 2014-2015 outbreak of Ebola virus (EBOV), originating from Guinea, is now responsible for the infection of >20,000 people in 9 countries. Whereas past filovirus outbreaks in sub-Saharan Africa have been rapidly brought under control with comparably few cases, this outbreak has been particularly resistant to containment efforts. Both the general population and primary health care workers have been affected by this outbreak, with hundreds of doctors and nurses being infected in the line of duty. In the absence of approved therapeutics, several caregivers have turned to investigational new drugs as well as experimental therapies in an effort to save lives. This review aims to summarize the candidates currently under consideration for postexposure use in infected patients during the largest EBOV outbreak in history.
2014 - 2015年埃博拉病毒（EBOV）疫情起源于几内亚，目前已导致9个国家的2万多人感染。过去在撒哈拉以南非洲爆发的丝状病毒疫情相对病例较少，能迅速得到控制，但此次疫情特别难以遏制。普通民众和初级卫生保健工作者都受到了此次疫情的影响，数百名医生和护士在履行职责时被感染。在没有获批治疗方法的情况下，一些护理人员转而使用研究性新药以及实验性疗法来挽救生命。本综述旨在总结在历史上最大规模的埃博拉病毒疫情期间，目前正在考虑用于感染患者暴露后治疗的候选药物。
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