Ghanemi Abdelaziz
Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
Saudi Pharm J. 2015 Apr;23(2):115-29. doi: 10.1016/j.jsps.2013.07.007. Epub 2013 Aug 13.
G protein coupled receptors (GPCRs) represent the most important targets in modern pharmacology because of the different functions they mediate, especially within brain and peripheral nervous system, and also because of their functional and stereochemical properties. In this paper, we illustrate, via a variety of examples, novel advances about the GPCR-related molecules that have been shown to play diverse roles in GPCR pathways and in pathophysiological phenomena. We have exemplified how those GPCRs' pathways are, or might constitute, potential targets for different drugs either to stimulate, modify, regulate or inhibit the cellular mechanisms that are hypothesized to govern some pathologic, physiologic, biologic and cellular or molecular aspects both in vivo and in vitro. Therefore, influencing such pathways will, undoubtedly, lead to different therapeutical applications based on the related pharmacological implications. Furthermore, such new properties can be applied in different fields. In addition to offering fruitful directions for future researches, we hope the reviewed data, together with the elements found within the cited references, will inspire clinicians and researchers devoted to the studies on GPCR's properties.
G蛋白偶联受体（GPCRs）是现代药理学中最重要的靶点，这是因为它们介导多种不同功能，尤其是在脑和外周神经系统中，还因为它们具有功能和立体化学特性。在本文中，我们通过各种实例阐述了与GPCR相关分子的新进展，这些分子已被证明在GPCR途径和病理生理现象中发挥着多种作用。我们举例说明了这些GPCR途径如何或可能构成不同药物的潜在靶点，这些药物可刺激、改变、调节或抑制细胞机制，这些细胞机制被认为在体内和体外控制着某些病理、生理、生物学以及细胞或分子方面。因此，基于相关药理学意义，影响这些途径无疑将导致不同的治疗应用。此外，这些新特性可应用于不同领域。除了为未来研究提供富有成效的方向外，我们希望所综述的数据以及参考文献中发现的内容能够激发致力于GPCR特性研究的临床医生和研究人员。
