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青少年接触甲基苯丙胺的影响。

The effects of adolescent methamphetamine exposure.

作者信息

Buck Jordan M, Siegel Jessica A

机构信息

Department of Psychology, Sewanee: The University of the South Sewanee, TN, USA.

出版信息

Front Neurosci. 2015 Apr 29;9:151. doi: 10.3389/fnins.2015.00151. eCollection 2015.

DOI:10.3389/fnins.2015.00151
PMID:25972781
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4413725/
Abstract

Methamphetamine use among adolescents is a significant social and public health concern. Despite increased awareness of methamphetamine use among younger people, relatively little research has examined the effects of adolescent methamphetamine use compared to adult use. Thus, much remains to be learned about how methamphetamine alters adolescent brain function and behavior. In this article we review recent trends in adolescent methamphetamine use and data examining the effects of adolescent methamphetamine use on the dopaminergic system and behavior in humans and animal models. Future research is warranted to expand our understanding of the effects of adolescent methamphetamine exposure and how those effects differ from those seen in adults.

摘要

青少年使用甲基苯丙胺是一个重大的社会和公共卫生问题。尽管人们对年轻人使用甲基苯丙胺的认识有所提高,但与成年人使用情况相比,针对青少年使用甲基苯丙胺的影响进行的研究相对较少。因此,关于甲基苯丙胺如何改变青少年大脑功能和行为,仍有许多有待了解的地方。在本文中,我们回顾了青少年使用甲基苯丙胺的最新趋势,以及关于青少年使用甲基苯丙胺对人类和动物模型中多巴胺能系统及行为影响的数据。有必要进行未来研究,以扩大我们对青少年接触甲基苯丙胺的影响以及这些影响与成年人有何不同的理解。

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本文引用的文献

1
Long-term effects of early adolescent methamphetamine exposure on depression-like behavior and the hypothalamic vasopressin system in mice.青春期早期接触甲基苯丙胺对小鼠抑郁样行为和下丘脑加压素系统的长期影响。
Dev Neurosci. 2014;36(2):108-18. doi: 10.1159/000360001. Epub 2014 Mar 27.
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Long-term effects of exposure to methamphetamine in adolescent rats.青少年大鼠暴露于甲基苯丙胺的长期影响。
Drug Alcohol Depend. 2014 May 1;138:17-23. doi: 10.1016/j.drugalcdep.2014.02.021. Epub 2014 Feb 26.
3
Depression and alterations in hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axis function in male abstinent methamphetamine abusers.男性戒毒后甲基苯丙胺滥用者的抑郁以及下丘脑 - 垂体 - 肾上腺和下丘脑 - 垂体 - 甲状腺轴功能的改变
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Decreased frontal N-acetylaspartate levels in adolescents concurrently using both methamphetamine and marijuana.青少年同时使用冰毒和大麻会导致额皮质 N-乙酰天门冬氨酸水平降低。
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Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit.慢性甲基苯丙胺暴露会导致延迟的、长期的记忆缺陷。
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Methamphetamine treatment during development attenuates the dopaminergic deficits caused by subsequent high-dose methamphetamine administration.发育期间给予甲基苯丙胺治疗可减轻随后大剂量给予甲基苯丙胺造成的多巴胺能缺陷。
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Psychiatric comorbidity in methamphetamine dependence.甲基苯丙胺依赖中的精神共病。
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Neuropsychological deficits in adolescent methamphetamine abusers.青少年冰毒滥用者的神经心理学缺陷。
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Psychiatric symptoms and HPA axis function in adolescent methamphetamine users.青少年甲基苯丙胺使用者的精神症状和 HPA 轴功能。
J Neuroimmune Pharmacol. 2010 Dec;5(4):582-91. doi: 10.1007/s11481-010-9206-y. Epub 2010 Apr 1.