Noack Julia, Murau Rita, Engelmann Mario
Center for Behavioral Brain Sciences, Institut für Biochemie und Zellbiologie, Otto-von-Guericke-Universität Magdeburg Magdeburg, Germany.
Front Neurosci. 2015 Apr 29;9:152. doi: 10.3389/fnins.2015.00152. eCollection 2015.
Different lines of investigation suggest that the medial amygdala is causally involved in the processing of information linked to social behavior in rodents. Here we investigated the consequences of temporary inhibition of the medial amygdala by bilateral injections of lidocaine on long-term social recognition memory as tested in the social discrimination task. Lidocaine or control NaCl solution was infused immediately before learning or before retrieval. Our data show that lidocaine infusion immediately before learning did not affect long-term memory retrieval. However, intra-amygdalar lidocaine infusions immediately before choice interfered with correct memory retrieval. Analysis of the aggressive behavior measured simultaneously during all sessions in the social recognition memory task support the impression that the lidocaine dosage used here was effective as it-at least partially-reduced the aggressive behavior shown by the experimental subjects toward the juveniles. Surprisingly, also infusions of NaCl solution blocked recognition memory at both injection time points. The results are interpreted in the context of the importance of the medial amygdala for the processing of non-volatile odors as a major contributor to the olfactory signature for social recognition memory.
不同的研究方向表明，内侧杏仁核在啮齿动物与社会行为相关的信息处理过程中起着因果作用。在此，我们通过双侧注射利多卡因暂时抑制内侧杏仁核，研究其对社会辨别任务中测试的长期社会识别记忆的影响。在学习前或检索前立即注入利多卡因或对照氯化钠溶液。我们的数据表明，学习前立即注入利多卡因不会影响长期记忆检索。然而，在选择前立即进行杏仁核内利多卡因注入会干扰正确的记忆检索。对社会识别记忆任务所有阶段同时测量的攻击行为的分析支持了这样一种印象，即此处使用的利多卡因剂量是有效的，因为它至少部分降低了实验对象对幼崽表现出的攻击行为。令人惊讶的是，在两个注射时间点注入氯化钠溶液也会阻断识别记忆。这些结果是在内侧杏仁核对非挥发性气味处理的重要性的背景下进行解释的，非挥发性气味是社会识别记忆嗅觉特征的主要贡献者。
