帕金森病中的血小板单胺氧化酶-B活性

Platelet monoamine oxidase-B activity in Parkinson's disease.

作者信息

Steventon G B, Sturman S G, Heafield M T, Waring R H, Napier J, Williams A C

机构信息

Department of Neurology, Queen Elizabeth Medical Centre, Birmingham, United Kingdom.

出版信息

J Neural Transm Park Dis Dement Sect. 1989;1(4):255-61. doi: 10.1007/BF02263479.

DOI:10.1007/BF02263479

PMID:2597311

Abstract

Platelet MAO-B levels have been investigated in seventeen consecutively diagnosed and previously untreated patients with idiopathic Parkinson's disease using the non-hydroxylated catecholamine, beta-phenylethylamine, as substrate. Patients with Parkinson's disease had MAO-B activity levels that were considerably higher than sex and age matched normal controls or patients with Motor neurone disease or Myasthenia gravis.

摘要

利用非羟基化儿茶酚胺β-苯乙胺作为底物，对17例连续确诊且先前未经治疗的特发性帕金森病患者的血小板单胺氧化酶B（MAO-B）水平进行了研究。帕金森病患者的MAO-B活性水平显著高于性别和年龄匹配的正常对照组、运动神经元病患者或重症肌无力患者。