Du Fangjuan, Yang Maowu, Fang Jingzhong, Jing Changchun
Department of Gastroenterology, The Second People's Hospital of Liaocheng Affiliated to Taishan Medical College Liaocheng 252600, Shandong, China.
Department of Ultrasonography, The Second People's Hospital of Liaocheng Affiliated to Taishan Medical College Liaocheng 252600, Shandong, China.
Int J Clin Exp Pathol. 2015 Feb 1;8(2):2199-201. eCollection 2015.
Primary hepatic malignant melanoma is a very rare disease. In order to provide clues concerning diagnosis, differential diagnosis and pathogenesis of the disease, a case of a 49 year-old female patient with primary hepatic malignant melanoma is presented. B-mode ultrasound and Contrast-enhanced abdominal computerized tomography (CT) examinations revealed that nodules of varying sizes are diffusely distributed in her enlarged liver. Pathological examination revealed that tumor cells with poor differentiation were located in nests with prominent melanin deposition. Immuno-histochemical staining showed that the tumor cells were positive for HMB-45 and S-100 protein. No evidence for primary malignant melanoma of other sites had been found by comprehensive examinations. Therefore, the patient was diagnosed with primary malignant melanoma of liver. Our case showed that primary malignant melanoma of liver is of histological heterogeneity, and immunohistochemical staining may aid in differential diagnosis between it and other hepatic neoplasms.
原发性肝恶性黑色素瘤是一种非常罕见的疾病。为了提供有关该疾病诊断、鉴别诊断和发病机制的线索，本文报告了一例49岁女性原发性肝恶性黑色素瘤患者。B超和腹部增强计算机断层扫描（CT）检查显示，在其肿大的肝脏中散在分布着大小不等的结节。病理检查显示，分化差的肿瘤细胞呈巢状分布，黑色素沉积明显。免疫组织化学染色显示肿瘤细胞HMB-45和S-100蛋白呈阳性。综合检查未发现其他部位原发性恶性黑色素瘤的证据。因此，该患者被诊断为肝原发性恶性黑色素瘤。我们的病例显示，肝原发性恶性黑色素瘤具有组织学异质性，免疫组织化学染色有助于其与其他肝脏肿瘤的鉴别诊断。
