Gong Li, Li Yan-Hong, Zhao Jian-Ye, Wang Xu-Xia, Zhu Shao-Jun, Zhang Wei
Department of Pathology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaanxi Province, China.
World J Gastroenterol. 2008 Aug 21;14(31):4968-71. doi: 10.3748/wjg.14.4968.
Primary malignant melanoma of the liver is an exceedingly rare tumor. Only 12 cases have been reported in the worldwide literature. We present a case of isolated malignant melanoma of the liver occurring in a 36-year-old Chinese male patient. Comprehensive dermatologic and ophthalmologic examinations revealed no evidence of a cutaneous or ocular primary lesion. Other lesions in brain, respiratory tract, lung, gastrointestinal tract and anus, were not demonstrated by serial position emission tomography (PET). Microscopic examination of the resected specimen revealed a malignant melanoma, which was confirmed by immunohistochemical staining for HMB-45, S-100 protein, melanoma-pan and vimentin. Moreover, electron microscopy demonstrated melanosomes in tumor cell cytoplasm. Our case shows that primary malignant melanoma may occur in the liver and should be considered when the histopathological appearance is not typical for other hepatic neoplasm.
原发性肝脏恶性黑色素瘤是一种极其罕见的肿瘤。全球文献中仅报道过12例。我们报告一例发生在一名36岁中国男性患者身上的孤立性肝脏恶性黑色素瘤病例。全面的皮肤科和眼科检查未发现皮肤或眼部原发性病变的证据。连续的正电子发射断层扫描（PET）未显示脑、呼吸道、肺、胃肠道和肛门的其他病变。对切除标本的显微镜检查显示为恶性黑色素瘤，通过HMB-45、S-100蛋白、黑色素瘤泛抗体和波形蛋白的免疫组织化学染色得以证实。此外，电子显微镜显示肿瘤细胞质中有黑素小体。我们的病例表明原发性恶性黑色素瘤可发生于肝脏，当组织病理学表现不符合其他肝脏肿瘤的典型特征时应予以考虑。
