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兆伏级光子束在癌症治疗中电子污染的评估:蒙特卡罗研究

Evaluation of electron contamination in cancer treatment with megavoltage photon beams: monte carlo study.

作者信息

Seif F, Bayatiani M R

机构信息

Associate Professor, Department of Medical Physics and Radiotherapy, Arak University of Medical Sciences and Khansari Hospital, Arak, Iran;

出版信息

J Biomed Phys Eng. 2015 Mar 4;5(1):31-8. eCollection 2015 Mar.

Abstract

BACKGROUND

Megavoltage beams used in radiotherapy are contaminated with secondary electrons. Different parts of linac head and air above patient act as a source of this contamination. This contamination can increase damage to skin and subcutaneous tissue during radiotherapy. Monte Carlo simulation is an accurate method for dose calculation in medical dosimetry and has an important role in optimization of linac head materials. The aim of this study was to calculate electron contamination of Varian linac.

MATERIALS AND METHOD

The 6MV photon beam of Varian (2100 C/D) linac was simulated by Monte Carlo code, MCNPX, based on its company's instructions. The validation was done by comparing the calculated depth dose and profiles of simulation with dosimetry measurements in a water phantom (error less than 2%). The Percentage Depth Dose (PDDs), profiles and contamination electron energy spectrum were calculated for different therapeutic field sizes (5×5 to 40×40 cm(2)) for both linacs.

RESULTS

The dose of electron contamination was observed to rise with increase in field size. The contribution of the secondary contamination electrons on the surface dose was 6% for 5×5 cm(2) to 27% for 40×40 cm(2), respectively.

CONCLUSION

Based on the results, the effect of electron contamination on patient surface dose cannot be ignored, so the knowledge of the electron contamination is important in clinical dosimetry. It must be calculated for each machine and considered in Treatment Planning Systems.

摘要

背景

放射治疗中使用的兆伏级射束会被二次电子污染。直线加速器机头的不同部位以及患者上方的空气是这种污染的来源。这种污染会在放射治疗期间增加对皮肤和皮下组织的损伤。蒙特卡罗模拟是医学剂量学中剂量计算的一种准确方法,在直线加速器机头材料的优化中具有重要作用。本研究的目的是计算瓦里安直线加速器的电子污染情况。

材料与方法

根据瓦里安公司的说明,使用蒙特卡罗代码MCNPX对瓦里安(2100 C/D)直线加速器的6MV光子束进行模拟。通过将模拟计算得到的深度剂量和剂量分布与水模体中的剂量学测量结果进行比较来进行验证(误差小于2%)。计算了两种直线加速器不同治疗野尺寸(5×5至40×40 cm²)的百分深度剂量(PDDs)、剂量分布和污染电子能谱。

结果

观察到电子污染剂量随野尺寸的增加而升高。二次污染电子对表面剂量的贡献分别为5×5 cm²时的6%至40×40 cm²时的27%。

结论

基于这些结果,电子污染对患者表面剂量 的影响不可忽视,因此在临床剂量学中了解电子污染情况很重要。必须针对每台机器进行计算并在治疗计划系统中予以考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/184e/4417618/ca25b13a8348/jbpe-5-31-g001.jpg

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