Sinclair J D, Li T K
Research Laboratories, Finnish State Alcohol Company, Alko Ltd., Helsinki.
Alcohol. 1989 Nov-Dec;6(6):505-9. doi: 10.1016/0741-8329(89)90059-1.
In contrast to all other strains of rats previously tested, the heavy-drinking AA rats were recently found not to increase their daily intake of alcohol after a week without ethanol. This result was now replicated with F52 generation male AAs using Wistars as controls. The same AAs, however, after being switched to a choice between 0.05% saccharin and water, showed a significant increase in saccharin drinking after being deprived of it for a week. Alcohol deprivation for 24 hr or less hardly affected the intake by Wistars during the first hour of renewed intake but sharply increased that by AAs. Still longer deprivation produced progressively smaller first-hour intakes in the AAs. Unlike the AAs, alcohol-preferring P rats showed an increase in alcohol drinking after a week of deprivation similar to that seen with normal rats. However, in common with the AAs, their first hour intake was increased significantly by only a few hours of alcohol deprivation.
与之前测试过的所有其他品系大鼠不同，重度饮酒的AA大鼠最近被发现，在一周不摄入乙醇后，其每日酒精摄入量并未增加。现在，以Wistar大鼠作为对照，对F52代雄性AA大鼠重复了这一结果。然而，同样的AA大鼠，在改为在0.05%糖精和水之间进行选择后，在被剥夺糖精一周后，糖精饮用量显著增加。对Wistar大鼠而言，24小时或更短时间的酒精剥夺，在重新摄入的第一小时内几乎不影响其摄入量，但对AA大鼠的摄入量则有显著增加。更长时间的剥夺使AA大鼠在第一小时的摄入量逐渐减少。与AA大鼠不同，偏好酒精的P品系大鼠在剥夺一周后酒精饮用量增加，这与正常大鼠的情况类似。然而，与AA大鼠相同的是，仅数小时的酒精剥夺就使其第一小时的摄入量显著增加。
