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酒精成瘾大鼠缺乏酒精剥夺效应。

Lack of alcohol-deprivation effect in AA rats.

作者信息

Sinclair J D, Tiihonen K

机构信息

Research Laboratory, Finnish Alcohol Company, Alko Ltd., Helsinki.

出版信息

Alcohol. 1988 Jan-Feb;5(1):85-7. doi: 10.1016/0741-8329(88)90048-1.

DOI:10.1016/0741-8329(88)90048-1
PMID:3355673
Abstract

Rats that have had at least several weeks of access to ethanol generally react to a week or more without it by drinking more alcohol on the first few days of renewed access. This alcohol-deprivation effect was again seen now in 25 male Long-Evans rats but not in 21 males of the heavy-drinking AA line. The present results obtained with F51 generation AAs differ from ones obtained previously with F32 AAs, which showed an initially small but long-lasting increase after deprivation, and may indicate a change produced by the intervening revitalization of the AA line.

摘要

那些至少有几周时间能够接触到乙醇的大鼠,在停止接触一周或更长时间后,通常会在重新接触乙醇的头几天饮用更多的酒。这种酒精剥夺效应现在在25只雄性Long-Evans大鼠中再次出现,但在21只重饮酒的AA系雄性大鼠中未出现。目前在F51代AA大鼠中获得的结果与之前在F32代AA大鼠中获得的结果不同,F32代AA大鼠在剥夺后最初显示出较小但持续时间长的增加,这可能表明AA系的中间复兴产生了变化。

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Lack of alcohol-deprivation effect in AA rats.酒精成瘾大鼠缺乏酒精剥夺效应。
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2
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The alcohol deprivation effect in the alcohol-preferring P rat under free-drinking and operant access conditions.自由饮用和操作性获取条件下,偏爱酒精的P大鼠的酒精剥夺效应。
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Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases.饮酒起始年龄对伴有剥夺和应激阶段的长期乙醇自我给药的影响。
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