Rao Madhwesha, Wild Jim M
Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom.
Magn Reson Med. 2016 Apr;75(4):1841-8. doi: 10.1002/mrm.25680. Epub 2015 May 13.
The hyperpolarized gases (3)He and (129)Xe have distinct properties and provide unique and complementary functional information from the lungs. A triple-nuclear, same-breath imaging examination of the lungs with (1)H, (3)He, and (129)Xe can therefore provide exclusive functional information from the gas images. In addition, the (1)H images provide complementary co-registered structural information in the same physiological time frame. The goal of this study was to design an RF system for triple nuclear lung MRI at 1.5T, consisting of a dual-tuned transceiver coil for (3)He and (129)Xe, RF switches and a nested (1)H receiver array.
A dual-tuned transmit-receive dual-Helmholtz RF coil for (3)He and (129)Xe was designed and constructed to work in unison with a nested (1)H receiver array.
Triple-nuclear imaging (structural and ventilation) and apparent diffusion coefficient mapping of the human lungs was performed in the same breath-hold using the integrated RF system. B1 maps and volumetric ventilation imaging using a three-dimensional, balanced steady-state free precession pulse sequence performed with both hyperpolarized (3)He and (129)Xe indicate good stand-alone performance of the coil for the respective nucleus.
Triple-nuclear same-breath lung imaging with a dual-tuned coil ((3)He and (129)Xe) and a nested (1)H array has been demonstrated with a custom RF system.
超极化气体（3）He和（129）Xe具有独特的性质，可提供来自肺部的独特且互补的功能信息。因此，利用（1）H、（3）He和（129）Xe对肺部进行三核同呼吸成像检查，能够从气体图像中获取独家功能信息。此外，（1）H图像在相同的生理时间框架内提供互补的配准结构信息。本研究的目标是设计一种用于1.5T三核肺部MRI的射频系统，该系统由用于（3）He和（129）Xe的双调谐收发线圈、射频开关以及嵌套式（1）H接收阵列组成。
设计并构建了一个用于（3）He和（129）Xe的双调谐发射 - 接收双亥姆霍兹射频线圈，使其与嵌套式（1）H接收阵列协同工作。
使用集成射频系统在同一次屏气过程中对人体肺部进行了三核成像（结构和通气）以及表观扩散系数映射。使用超极化（3）He和（129）Xe通过三维、平衡稳态自由进动脉冲序列进行的B1图和容积通气成像表明，该线圈对于相应原子核具有良好的独立性能。
利用定制射频系统已实现了使用双调谐线圈（（3）He和（129）Xe）及嵌套式（1）H阵列进行三核同呼吸肺部成像。
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