Yu L S, Yuan B, Bishop D, Topaz S, van Griensven J, Hofma S, Swier P, Klinkmann J, Kolff J, Kolff W J
Department of Surgery, University of Utah, Salt Lake City 84112.
ASAIO Trans. 1989 Jul-Sep;35(3):301-4. doi: 10.1097/00002480-198907000-00040.
This article describes new bistable valves, and introduces a new soft heart that is easy to implant. Earlier, five polyurethane (PU) valves were implanted in the mitral position in sheep. All five survived for 1 year or more, and the valves, although calcified, were intact. Since the opening resistance was somewhat high, valves that are bistable were developed, which means they may be open or closed. These valves have lower opening resistance, and regurgitation is similar to that of mechanical valves. Eight calves have been implanted with a new, soft total artificial heart (TAH). Seven had bistable leaflet valves; the eighth had mechanical (Bicer) valves in the inflow position. Four of the calves were sacrificed after 22 to 43 days. At autopsy, the number of thromboemboli found, particularly in the kidneys, was low compared with previous experiments. None of these animals received anticoagulants other than the heparin given during heart/lung bypass.
本文介绍了新型双稳态瓣膜，并引入了一种易于植入的新型柔软人工心脏。此前，五只聚氨酯（PU）瓣膜被植入绵羊的二尖瓣位置。所有五只绵羊均存活了1年或更长时间，瓣膜虽有钙化但仍保持完整。由于开启阻力有些高，因此开发了双稳态瓣膜，即它们可以处于打开或关闭状态。这些瓣膜的开启阻力较低，反流情况与机械瓣膜相似。八只小牛植入了新型柔软全人工心脏（TAH）。七只小牛植入了双稳态瓣叶瓣膜；第八只小牛在流入道位置植入了机械（比塞尔）瓣膜。四只小牛在22至43天后被处死。尸检发现，与之前的实验相比，血栓栓塞的数量较少，尤其是在肾脏中。除了在心肺转流期间给予的肝素外，这些动物均未接受其他抗凝剂治疗。
