Cihoric Nikola, Tsikkinis Alexandros, van Rhoon Gerard, Crezee Hans, Aebersold Daniel M, Bodis Stephan, Beck Marcus, Nadobny Jacek, Budach Volker, Wust Peter, Ghadjar Pirus
a Department of Radiation Oncology, Inselspital , Bern University Hospital, and University of Bern .
b Erasmus MC Cancer Institute, Department of Radiation Oncology , Rotterdam , The Netherlands .
Int J Hyperthermia. 2015;31(6):609-14. doi: 10.3109/02656736.2015.1040471. Epub 2015 May 15.
Hyperthermia has been shown to improve the effectiveness of chemotherapy and radiotherapy in the treatment of cancer. This paper summarises all recent clinical trials registered in the ClinicalTrials.gov registry.
The records of 175,538 clinical trials registered at ClinicalTrials.gov were downloaded on 29 September 2014 and a database was established. We searched this database for hyperthermia or equivalent words.
A total of 109 trials were identified in which hyperthermia was part of the treatment regimen. Of these, 49 trials (45%) had hyperthermic intraperitoneal chemotherapy after cytoreductive surgery (HIPEC) as the primary intervention, and 14 other trials (13%) were also testing some form of intraperitoneal hyperthermic chemoperfusion. Seven trials (6%) were testing perfusion attempts to other locations (thoracic/pleural n = 4, limb n = 2, hepatic n = 1). Sixteen trials (15%) were testing regional hyperthermia, 13 trials (12%) whole body hyperthermia, seven trials (6%) superficial hyperthermia and two trials (2%) interstitial hyperthermia. One remaining trial tested laser hyperthermia.
In contrast to the general opinion, this analysis shows continuous interest and ongoing clinical research in the field of hyperthermia. Interestingly, the majority of trials focused on some form of intraperitoneal hyperthermic chemoperfusion. Despite the high number of active clinical studies, HIPEC is a topic with limited attention at the annual meetings of the European Society for Hyperthermic Oncology and the Society of Thermal Medicine. The registration of on-going clinical trials is of paramount importance for the achievement of a comprehensive overview of available clinical research activities involving hyperthermia.
热疗已被证明可提高化疗和放疗在癌症治疗中的效果。本文总结了ClinicalTrials.gov注册库中所有近期的临床试验。
2014年9月29日下载了ClinicalTrials.gov注册的175,538项临床试验记录，并建立了一个数据库。我们在该数据库中搜索热疗或等效词汇。
共识别出109项试验，其中热疗是治疗方案的一部分。其中，49项试验（45%）以减瘤手术后的热灌注腹腔化疗（HIPEC）作为主要干预措施，另外14项试验（13%）也在测试某种形式的腹腔内热化疗灌注。7项试验（6%）在测试对其他部位的灌注尝试（胸部/胸膜n = 4，肢体n = 2，肝脏n = 1）。16项试验（15%）在测试区域热疗，13项试验（12%）全身热疗，7项试验（6%）浅表热疗，2项试验（2%）间质热疗。其余1项试验测试激光热疗。
与普遍看法相反，该分析表明在热疗领域持续存在兴趣且正在进行临床研究。有趣的是，大多数试验集中在某种形式的腹腔内热化疗灌注。尽管有大量活跃的临床研究，但在欧洲热疗肿瘤学会和热医学学会的年会上，HIPEC是一个关注度有限的主题。正在进行的临床试验的注册对于全面概述涉及热疗的现有临床研究活动至关重要。
