Wang Na, Liu Pu, Zhao Qi, Zhao Yanping, Jiang Feng, Fang Hong, Fu Chaowei, Xu Huilin, Wang Hexing, Yan Yujie, Zhou Ying, Jiang Qingwu
The Key Laboratory of Public Health Safety, Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200021, China.
Shanghai Minhang Center for Disease Control and Prevention.
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Mar;36(3):237-40.
To analyze the association between thyroid volume and physical growth of school-age children, and to compare volume indexes of individual thyroids for reference of selection of assessment indicators.
All the students of the 12 classes of grades 3-5 at a primary school in Minhang district, Shanghai were rounded up with a multi-stage cluster sampling, for physical examinations to measure their height, weight, Body mass index (BMI) and body surface area (BSA), followed by B-ultrasonography to measure their thyroid volume. Data of the measurements were calculated to learn their height corrected volume index (HVI), weight and height corrected volume index (WHVI), BMI corrected volume (BMIV), and BSA corrected volume (BSAV) individually. Their urine and salt samples were collected to measure iodine concentration in urine and salt. Individual indexes were studied for their association with the growth and development indexes of children.
Thyroid volume data were collected for 485 students, including 258 boys (53.2%) and 227 girls (46.8%). Their height, weight, BMI and BSA were found to be positively correlated with their age (P < 0.05). For children of the same age group, their thyroid volume was also positively correlated with their physical development indexes. Of all the thyroid indexes, the difference between BSAV physical development factors had no statistical association (with partial-correlation coefficients for age, gender, height, and weight being 0.07, 0.05, 0.01 and 0.02 respectively), and their thyroid volume, HVI, BMI and weight were correlated to age, height and weight.
Thyroid volume was associated with age and weight. It was inappropriate to diagnose goiter with criteria of age, gender and thyroid volume. BSAV was recommended for its non-association with age, gender and weight and its stability.
分析学龄儿童甲状腺体积与身体生长发育之间的关联，并比较个体甲状腺体积指数，为评估指标的选择提供参考。
采用多阶段整群抽样方法，对上海市闵行区某小学三至五年级的12个班级全体学生进行体检，测量身高、体重、体质指数（BMI）和体表面积（BSA），随后通过B超测量甲状腺体积。计算测量数据，分别得出身高校正体积指数（HVI）、体重与身高校正体积指数（WHVI）、BMI校正体积（BMIV）和BSA校正体积（BSAV）。采集学生尿样和盐样，测量尿碘和盐碘浓度。研究各项个体指标与儿童生长发育指标之间的关联。
共收集485名学生的甲状腺体积数据，其中男生258名（53.2%），女生227名（46.8%）。发现他们的身高、体重、BMI和BSA与年龄呈正相关（P<0.05）。对于同一年龄组的儿童，其甲状腺体积也与身体发育指标呈正相关。在所有甲状腺指数中，BSAV与身体发育因素之间的差异无统计学关联（年龄、性别、身高和体重的偏相关系数分别为0.07、0.05、0.01和0.02），其甲状腺体积、HVI、BMI和体重与年龄、身高和体重相关。
甲状腺体积与年龄和体重有关。采用年龄、性别和甲状腺体积标准诊断甲状腺肿并不合适。建议使用BSAV，因其与年龄、性别和体重无关且具有稳定性。
