Department of Ultrasonic, The First People's Hospital of Xiaoshan, Hangzhou, China.
Department of Oncology, The First People's Hospital of Xiaoshan, Hangzhou, China.
J Pediatr Endocrinol Metab. 2020 Dec 14;34(2):231-236. doi: 10.1515/jpem-2020-0422. Print 2021 Feb 23.
To investigate the thyroid volume (Tvol) and to explore factors that affects it among 12 to 15-year-olds attending a rural middle school in east Hangzhou, China.
A cross-sectional survey of middle school students attending a rural middle school in east Hangzhou, China was conducted. Height, weight and other physical development related indicators in middle school students were measured. The thyroid size was measured using ultrasound, and the thyroid volume calculated.
The median (P, P) of the thyroid volume in 596 middle school students from a rural middle school in east Hangzhou, China was 6.69 (5.66, 7.98) mL. Our study enrolled 305 male students (51.2%) and 291 female students (48.8%). The height, weight and thyroid volume of middle school students increased with age. Univariate analysis revealed that height, weight, body mass index (BMI) and body surface area (BSA) were positive correlated with thyroid volume (p<0.01).The correlation between BSA and thyroid volume was significant (Spearman's rho=0.473, p<0.01). Multiple linear regression analysis revealed that BSA was positive and significantly correlated with the thyroid volume (p<0.05). Regression equation was Y=-2.532 + 6.186×BSA.
The thyroid volume is not only affected by age, but it is also affected by growth and development. Goiter cannot only be assessed based on age, gender and thyroid volume. However, this study established that BSA not only presented the strongest correlation with thyroid volume (Spearman's rho=0.473), but also had a strong correlation with physical development, taking into account the growth and development of middle school students, and showed greater stability. Therefore, we recommend inclusion of BSA as a reference standard in the measurement of the thyroid volume.
研究中国杭州市东部农村一所中学 12 至 15 岁青少年的甲状腺体积（Tvol）并探讨影响其甲状腺体积的因素。
对中国杭州市东部农村一所农村中学的中学生进行横断面调查。测量中学生的身高、体重和其他与身体发育相关的指标。使用超声测量甲状腺大小，并计算甲状腺体积。
中国杭州市东部农村一所农村中学的 596 名中学生的甲状腺体积中位数（P，P）为 6.69（5.66，7.98）mL。我们的研究纳入了 305 名男生（51.2%）和 291 名女生（48.8%）。中学生的身高、体重和甲状腺体积随年龄增长而增加。单因素分析显示，身高、体重、体重指数（BMI）和体表面积（BSA）与甲状腺体积呈正相关（p<0.01）。BSA 与甲状腺体积的相关性显著（Spearman 相关系数=0.473，p<0.01）。多元线性回归分析显示，BSA 与甲状腺体积呈正相关且具有统计学意义（p<0.05）。回归方程为 Y=-2.532+6.186×BSA。
甲状腺体积不仅受年龄影响，还受生长发育影响。甲状腺肿不能仅根据年龄、性别和甲状腺体积进行评估。然而，本研究表明 BSA 不仅与甲状腺体积呈最强相关性（Spearman 相关系数=0.473），而且与身体发育密切相关，考虑到中学生的生长发育，BSA 显示出更大的稳定性。因此，我们建议将 BSA 纳入甲状腺体积测量的参考标准。
