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用于个性化定制植入物的3D硅橡胶界面。

3D silicone rubber interfaces for individually tailored implants.

作者信息

Stieghorst Jan, Bondarenkova Alexandra, Burblies Niklas, Behrens Peter, Doll Theodor

机构信息

Cluster of Excellence Hearing4all, Hannover, Germany,

出版信息

Biomed Microdevices. 2015;17(3):9960. doi: 10.1007/s10544-015-9960-y.

Abstract

For the fabrication of customized silicone rubber based implants, e.g. cochlear implants or electrocortical grid arrays, it is required to develop high speed curing systems, which vulcanize the silicone rubber before it runs due to a heating related viscosity drop. Therefore, we present an infrared radiation based cross-linking approach for the 3D-printing of silicone rubber bulk and carbon nanotube based silicone rubber electrode materials. Composite materials were cured in less than 120 s and material interfaces were evaluated with scanning electron microscopy. Furthermore, curing related changes in the mechanical and cell-biological behaviour were investigated with tensile and WST-1 cell biocompatibility tests. The infrared absorption properties of the silicone rubber materials were analysed with fourier transform infrared spectroscopy in transmission and attenuated total reflection mode. The heat flux was calculated by using the FTIR data, emissivity data from the infrared source manufacturer and the geometrical view factor of the system.

摘要

为了制造定制的硅橡胶基植入物,例如人工耳蜗或脑电皮层网格阵列,需要开发高速固化系统,该系统可在硅橡胶因加热导致粘度下降而流动之前将其硫化。因此,我们提出了一种基于红外辐射的交联方法,用于3D打印硅橡胶本体和碳纳米管基硅橡胶电极材料。复合材料在不到120秒的时间内固化,并通过扫描电子显微镜评估材料界面。此外,通过拉伸和WST-1细胞生物相容性测试研究了固化相关的机械和细胞生物学行为变化。利用傅里叶变换红外光谱在透射和衰减全反射模式下分析了硅橡胶材料的红外吸收特性。通过使用FTIR数据、红外源制造商的发射率数据和系统的几何视角因子来计算热通量。

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