纳米二氧化钛添加到医用硅橡胶弹性体中的生物力学性能：人工老化的影响。

Biomechanical properties of nano-TiO(2) addition to a medical silicone elastomer: the effect of artificial ageing.

作者信息

Wang Linlin, Liu Qi, Jing Dongdong, Zhou Shanyu, Shao Longquan

机构信息

Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

出版信息

J Dent. 2014 Apr;42(4):475-83. doi: 10.1016/j.jdent.2014.01.002. Epub 2014 Jan 9.

DOI:10.1016/j.jdent.2014.01.002

PMID:24412587

Abstract

OBJECTIVES

The aim of this study was to evaluate the effect of TiO2 nanoparticles on the mechanical and anti-ageing properties of a medical silicone elastomer and to assess the biocompatibility of this novel combination.

METHODS

TiO2 (P25, Degussa, Germany) nanoparticles were mixed with the silicone elastomer (MDX4-4210, Dow Corning, USA) at 2%, 4%, and 6% (w/w) using silicone fluid as diluent (Q7-9180, Dow Corning, USA). Blank silicone elastomer served as the control material. The physical properties and biocompatibility of the composites were examined. The tensile strength was tested for 0% and 6% (w/w) before and after artificial ageing. SEM analysis was performed.

RESULTS

TiO2 nanoparticles improved the tensile strength and Shore A hardness of the silicone elastomer (P<0.05). However, a decrease in the elongation at break and tear strength was found for the 6% (w/w) composite (P<0.05). All the ageing methods had no effect on the tensile strength of the 6% (w/w) composite (P>0.05), but thermal ageing significantly decreased the tensile strength of the control group (P<0.05). Cellular viability assays indicated that the composite exhibited biocompatibility.

CONCLUSIONS

We obtained a promising restorative material which yields favourable physical and anti-ageing properties and is biocompatible in our in vitro cellular studies.

摘要

目的

本研究旨在评估二氧化钛纳米颗粒对医用硅橡胶弹性体机械性能和抗老化性能的影响，并评估这种新型组合的生物相容性。

方法

使用硅油（美国道康宁公司Q7-9180）作为稀释剂，将二氧化钛（德国德固赛公司P25）纳米颗粒与硅橡胶弹性体（美国道康宁公司MDX4-4210）按2%、4%和6%（w/w）的比例混合。空白硅橡胶弹性体作为对照材料。对复合材料的物理性能和生物相容性进行了检测。对0%和6%（w/w）的复合材料在人工老化前后进行了拉伸强度测试。进行了扫描电子显微镜分析。

结果

二氧化钛纳米颗粒提高了硅橡胶弹性体的拉伸强度和邵氏A硬度（P<0.05）。然而，6%（w/w）的复合材料的断裂伸长率和撕裂强度有所下降（P<0.05）。所有老化方法对6%（w/w）复合材料的拉伸强度均无影响（P>0.05），但热老化显著降低了对照组的拉伸强度（P<0.05）。细胞活力测定表明该复合材料具有生物相容性。