Lenarz Thomas
Department of Otolaryngology, Head & Neck Surgery, Hannover Medical School, Hannover, Germany.
GMS Curr Top Otorhinolaryngol Head Neck Surg. 2018 Feb 19;16:Doc04. doi: 10.3205/cto000143. eCollection 2017.
Cochlear implants are the treatment of choice for auditory rehabilitation of patients with sensory deafness. They restore the missing function of inner hair cells by transforming the acoustic signal into electrical stimuli for activation of auditory nerve fibers. Due to the very fast technology development, cochlear implants provide open-set speech understanding in the majority of patients including the use of the telephone. Children can achieve a near to normal speech and language development provided their deafness is detected early after onset and implantation is performed quickly thereafter. The diagnostic procedure as well as the surgical technique have been standardized and can be adapted to the individual anatomical and physiological needs both in children and adults. Special cases such as cochlear obliteration might require special measures and re-implantation, which can be done in most cases in a straight forward way. Technology upgrades count for better performance. Future developments will focus on better electrode-nerve interfaces by improving electrode technology. An increased number of electrical contacts as well as the biological treatment with regeneration of the dendrites growing onto the electrode will increase the number of electrical channels. This will give room for improved speech coding strategies in order to create the bionic ear, i.e. to restore the process of natural hearing by means of technology. The robot-assisted surgery will allow for high precision surgery and reliable hearing preservation. Biological therapies will support the bionic ear. Methods are bio-hybrid electrodes, which are coded by stem cells transplanted into the inner ear to enhance auto-production of neurotrophins. Local drug delivery will focus on suppression of trauma reaction and local regeneration. Gene therapy by nanoparticles will hopefully lead to the preservation of residual hearing in patients being affected by genetic hearing loss. Overall the cochlear implant is a very powerful tool to rehabilitate patients with sensory deafness. More than 1 million of candidates in Germany today could benefit from this high technology auditory implant. Only 50,000 are implanted so far. In the future, the procedure can be done under local anesthesia, will be minimally invasive and straight forward. Hearing preservation will be routine.
人工耳蜗是感音神经性耳聋患者听觉康复的首选治疗方法。它们通过将声信号转化为电刺激来激活听神经纤维,从而恢复内耳毛细胞缺失的功能。由于技术发展非常迅速,人工耳蜗能使大多数患者实现开放式言语理解,包括使用电话。如果儿童在耳聋发病后早期被检测出来,并随后迅速进行植入手术,他们能够实现接近正常的言语和语言发育。诊断程序和手术技术已经标准化,可以根据儿童和成人的个体解剖和生理需求进行调整。特殊情况如耳蜗闭塞可能需要特殊措施和再次植入,大多数情况下可以直接进行。技术升级有助于提高性能。未来的发展将集中在通过改进电极技术来实现更好的电极 - 神经接口。增加电触点数量以及对生长在电极上的树突进行再生的生物处理将增加电通道数量。这将为改进语音编码策略提供空间,以创造仿生耳,即通过技术恢复自然听力过程。机器人辅助手术将实现高精度手术并可靠地保留听力。生物疗法将支持仿生耳。方法包括生物混合电极,通过向内耳移植干细胞进行编码以增强神经营养因子的自身产生。局部药物递送将专注于抑制创伤反应和局部再生。纳米颗粒基因疗法有望在受遗传性听力损失影响的患者中保留残余听力。总体而言,人工耳蜗是使感音神经性耳聋患者康复的非常强大的工具。如今德国有超过100万患者可能从这种高科技听觉植入物中受益。到目前为止,只有5000人接受了植入。未来,该手术可以在局部麻醉下进行,将是微创且直接的。保留听力将成为常规操作。