Mayer M, Simon U, Strosche H, Schonfeld W
Br J Clin Pract. 1989 Jul;43(7):246-8.
Mezlocillin concentrations in the pleural fluid and serum of six patients with malignant pleural effusion were determined following administration of 10 g mezlocillin over 30 minutes as a rapid infusion. Thirty minutes and eight hours after the infusion had been completed, concentrations of the active ingredient in the pleural fluid were 36.44 micrograms/ml and 112 micrograms/ml respectively; in the serum the respective values were 777.89 micrograms/ml and 44.22 micrograms/ml. The concentrations of active ingredient in the pleural fluid exceed the MIC for clinically significant pathogenic germs. The elimination half-life of mezlocillin in malignant pleural effusion is prolonged.
对6例恶性胸腔积液患者在30分钟内快速输注10克美洛西林后，测定其胸腔积液和血清中的美洛西林浓度。输注完成后30分钟和8小时，胸腔积液中活性成分的浓度分别为36.44微克/毫升和112微克/毫升；血清中的相应值分别为777.89微克/毫升和44.22微克/毫升。胸腔积液中活性成分的浓度超过了对具有临床意义的致病微生物的最低抑菌浓度。美洛西林在恶性胸腔积液中的消除半衰期延长。
