Barrueco M, Garcia M J, Otero M J, Dominguez-Gil A, de Letona J M
Clin Ther. 1981;3(6):425-35.
The pharmacokinetics of cefoxitin were studied in nine patients with pleural effusion of varied etiologies. All patients received a single intravenous bolus of 30 mg/kg. Cefoxitin levels were determined simultaneously in plasma and pleural fluid by means of a microbiologic plate diffusion method. The antibiotic follows a two-compartment open kinetic model. In the pleural fluid, maximum concentrations of cefoxitin of 19.72 +/- 9.72 microgram/ml were reached two hours after administration. The fraction of the antibiotic that reaches the pleural fluid represents 0.22% to 4.03% of the dose administered. The disappearance constant of the antibiotic from the pleural fluid is significantly smaller (Kd = 0.15 +/- 0.03 hours-1) than the elimination constant determined from the plasma levels (K13 = 2.27 +/- 0.90 hours-1). Cefoxitin was always found in antibacterial concentration in the pleural fluid for a considerable period of time.
在9例不同病因的胸腔积液患者中研究了头孢西丁的药代动力学。所有患者均接受30mg/kg的单次静脉推注。采用微生物平板扩散法同时测定血浆和胸腔积液中的头孢西丁水平。该抗生素遵循二室开放动力学模型。在胸腔积液中，给药后2小时头孢西丁的最高浓度达到19.72±9.72μg/ml。到达胸腔积液的抗生素分数占给药剂量的0.22%至4.03%。抗生素从胸腔积液中的消失常数（Kd = 0.15±0.03小时-1）明显小于从血浆水平测定的消除常数（K13 = 2.27±0.90小时-1）。在相当长的一段时间内，胸腔积液中总能检测到具有抗菌浓度的头孢西丁。
