Knöller J, Schönfeld W, Mayer M, König W
Lehrstuhl für Med. Mikrobiologie und Immunologie, Ruhr-Universität, Bochum.
Zentralbl Bakteriol Mikrobiol Hyg A. 1988 May;268(3):370-5. doi: 10.1016/s0176-6724(88)80022-1.
Mezlocillin concentrations in the pleural fluid of six patients (42-76 years of age, suffering from cytologically confirmed malignant pleural effusions) were determined after intravenous infusion of 10 g mezlocillin. Serum and pleural fluid samples were withdrawn 15, 30, 45, 60 min, 2, 4, and 8 h post infusion. Detection of mezlocillin and its metabolites penicilloic acid and penilloic acid was carried out by means of high performance liquid chromatography (HPLC). Mezlocillin concentrations in serum increased up to 778 +/- 270 micrograms/ml after 15 min, steadily decreasing to 55 +/- 50 micrograms/ml (8 hours post infusion) comparable to the known pharmacokinetic behaviour of mezlocillin; in the pleural effusions mezlocillin levels increased up to 100 +/- 38 micrograms/ml after 1 h. This concentration was maintained throughout the following 7 h. Penicilloic levels ranged about 2-4% within serum, whereas levels below 1% were measured in the pleural fluid.
对6例患者（年龄42 - 76岁，经细胞学确诊为恶性胸腔积液）静脉输注10克美洛西林后，测定其胸腔积液中美洛西林的浓度。在输注后15、30、45、60分钟、2、4和8小时采集血清和胸腔积液样本。采用高效液相色谱法（HPLC）检测美洛西林及其代谢产物青霉噻唑酸和青霉烯酸。输注15分钟后血清中美洛西林浓度升至778±270微克/毫升，随后稳步下降至55±50微克/毫升（输注后8小时），这与已知的美洛西林药代动力学行为相符；胸腔积液中美洛西林水平在1小时后升至100±38微克/毫升，并在接下来的7小时内维持该浓度。血清中青霉噻唑酸水平约为2 - 4%，而胸腔积液中该水平低于1%。
