Mitsui A, Tada Y, Takahashi T, Shibata S, Kamata M, Miyagaki T, Fujita H, Sugaya M, Kadono T, Sato S, Asano Y
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Clin Exp Dermatol. 2016 Mar;41(2):183-9. doi: 10.1111/ced.12670. Epub 2015 May 15.
Interleukin (IL)-33 is a recently identified cytokine, which is a member of the IL-1 family and binds to a heterodimeric receptor comprising ST2 (suppression of tumorigenicity 2) and IL-1 receptor accessory protein. Serum levels of IL-33 have been reported to be upregulated in various T helper (Th)1/Th17-mediated diseases, such as rheumatoid arthritis and inflammatory bowel disease. IL-33 expression is increased in lesional skin in patients with psoriasis, but serum levels in patients with psoriasis have not yet been studied.
To study serum IL-33 levels in patients with psoriasis, a Th1/Th17-mediated skin disease, before and after anti-tumour necrosis factor (TNF)-α therapy.
Serum IL-33 levels were measured in patients with psoriasis vulgaris (PV), psoriatic arthritis (PsA) or pustular psoriasis (PP), and compared with those of healthy controls. Associations between serum IL-33 levels and serum TNF-α, IL-6, vascular endothelial growth factor and C-reactive protein levels were also studied. In addition, the effect of IL-33 stimulation on IL-6, IL-8, TNF-α and VEGF secretion by human keratinocyte was analysed.
Serum IL-33 levels in patients with PV, PsA and PP were significantly higher than those in healthy controls. Serum IL-33 levels correlated with serum TNF-α levels in patients with psoriasis, and decreased after anti-TNF-α therapy. IL-33 stimulated IL-6 and IL-8 secretion by human keratinocytes.
These results suggest that serum IL-33 levels generally reflect increased inflammation in patients with psoriasis.
白细胞介素（IL）-33是一种最近发现的细胞因子，它是IL-1家族的成员，可与由ST2（肿瘤抑制因子2）和IL-1受体辅助蛋白组成的异二聚体受体结合。据报道，在各种T辅助（Th）1/Th17介导的疾病中，如类风湿性关节炎和炎症性肠病，血清IL-33水平会上调。银屑病患者皮损处的IL-33表达增加，但银屑病患者的血清水平尚未得到研究。
研究抗肿瘤坏死因子（TNF）-α治疗前后，银屑病（一种Th1/Th17介导的皮肤病）患者的血清IL-33水平。
测量寻常型银屑病（PV）、银屑病关节炎（PsA）或脓疱型银屑病（PP）患者的血清IL-33水平，并与健康对照者进行比较。还研究了血清IL-33水平与血清TNF-α、IL-6、血管内皮生长因子和C反应蛋白水平之间的关联。此外，分析了IL-33刺激对人角质形成细胞分泌IL-6、IL-8、TNF-α和VEGF的影响。
PV、PsA和PP患者的血清IL-33水平显著高于健康对照者。银屑病患者的血清IL-33水平与血清TNF-α水平相关，且在抗TNF-α治疗后降低。IL-33刺激人角质形成细胞分泌IL-6和IL-8。
这些结果表明，血清IL-33水平通常反映了银屑病患者炎症的增加。
