Bajaj Anurag, Saleeb Michael, Rathor Parul, Sehgal Vishal, Kabak Besher, Hosur Srikanth
The Wright Center for Graduate Medical Education, 501 Madison Avenue, Scranton, PA, USA.
The Wright Center for Graduate Medical Education, 501 Madison Avenue, Scranton, PA, USA.
Heart Lung. 2015 Jul-Aug;44(4):327-34. doi: 10.1016/j.hrtlng.2015.03.007. Epub 2015 May 11.
The objective of our meta-analysis is to update the evidence on the prognostic value of elevated troponin levels in patient with acute normotensive pulmonary embolism (PE). We did a systematic literature review of database, including Pubmed, EMBASE, and Cochrane. Studies were included if those were done on normotensive patients with acute PE and serum troponin assay was done. The primary end point was short term all cause mortality. The secondary end points were short term PE related mortality and serious adverse events. Elevated troponin levels were significantly associated with the increased risk for short term mortality (odds ratio [OR], 4.80; 95% CI, 3.25-7.08, I(2) = 54%), PE related mortality (OR, 3.80; 95% CI, 2.74-5.27, I(2) = 0%) and serious adverse events (OR, 3.65; 95% CI, 2.41-5.53, I(2) = 47%). Our study suggests that elevated levels of troponin identify a subgroup of patients with increased risk for short term mortality and serious adverse events.
我们进行荟萃分析的目的是更新关于急性血压正常的肺栓塞（PE）患者肌钙蛋白水平升高的预后价值的证据。我们对包括PubMed、EMBASE和Cochrane在内的数据库进行了系统的文献综述。纳入的研究需是针对血压正常的急性PE患者且进行了血清肌钙蛋白检测。主要终点是短期全因死亡率。次要终点是短期PE相关死亡率和严重不良事件。肌钙蛋白水平升高与短期死亡率增加（比值比[OR]，4.80；95%置信区间[CI]，3.25 - 7.08，I² = 54%）、PE相关死亡率（OR，3.80；95% CI，2.74 - 5.27，I² = 0%）和严重不良事件（OR，3.65；95% CI，2.41 - 5.53，I² = 47%）显著相关。我们的研究表明，肌钙蛋白水平升高可识别出短期死亡率和严重不良事件风险增加的患者亚组。
