Eraghi Amir Sobhani, Kaseb Mohammad Hasan, Espandar Ramin, Mardookhpour Shirin
Department of Orthopedics, Rasoul Akram Hospital, Iran University of Medical sciences, Tehran, Iran.
Department of Orthopedics, Imam Khomeini Hospital, Tehran University of Medical sciences, Tehran, Iran.
Blood Cells Mol Dis. 2015 Jun;55(1):68-70. doi: 10.1016/j.bcmd.2015.03.011. Epub 2015 Mar 30.
Radioactive synoviorthesis was carried out by an injection of radioactive materials into the joint that has been known as a successful alternative treatment to invasive surgical synovectomy. This study was designed to evaluate short-term and long-term results and complications of radioactive synovectomy of hemophilic arthropathy using radioactive phosphorus.
This study was conducted on 40 patients with hemophilic arthropathy. After obtaining clotting factors, the intra-articular injections of radioactive phosphorus were done. Thirteen patients were evaluated during 36 months (short-term follow-up) and 27 patients were followed up for more than 36 months (long-term follow-up). Patients were evaluated for hemarthrosis, factor consumption per month, joint range of motion (ROM) and clinical and radiological involvement grade.
The patients mean age was 22.9 ± 6.6 and there were 38 men and 2 women. Consumption of clotting factors was significantly reduced in the short-term follow-up of patients (p < 0.05), but there was no significant difference in the long-term follow-up (p > 0.05). ROM decreased significantly in the long-term follow-up (p < 0.05). Radiologic evaluation showed significantly increased involvement in their joints (p < 0.05).
Using radioactive synoviorthesis led in decreased consumption of clotting factors and the hemarthrosis incidence in short term but it did not have significant impact on clinical situation (ROM) and radiological findings of hemophilic patients in long-term follow-up.
放射性滑膜切除术是通过向关节内注射放射性物质来进行的，这已被认为是侵入性手术滑膜切除术的一种成功替代治疗方法。本研究旨在评估使用放射性磷进行血友病性关节病放射性滑膜切除术的短期和长期结果及并发症。
本研究对40例血友病性关节病患者进行。在获得凝血因子后，进行关节内放射性磷注射。13例患者在36个月内接受评估（短期随访），27例患者随访超过36个月（长期随访）。对患者进行关节积血、每月凝血因子消耗、关节活动范围（ROM）以及临床和放射学受累程度评估。
患者平均年龄为22.9±6.6岁，男性38例，女性2例。患者短期随访中凝血因子消耗显著降低（p<0.05），但长期随访中无显著差异（p>0.05）。长期随访中ROM显著降低（p<0.05）。放射学评估显示其关节受累程度显著增加（p<0.05）。
使用放射性滑膜切除术在短期内导致凝血因子消耗减少和关节积血发生率降低，但在长期随访中对血友病患者的临床状况（ROM）和放射学表现没有显著影响。
