Nemati Ali, Moghadam Reza Alipanah, Mazani Mohammad, Darvishi Akram
Ardabil University of Medical Sciences, Ardabil, Iran.
J Pak Med Assoc. 2019 Mar;69(3):343-348.
To investigate the efficacy of L-carnitine (LC) and conjugated linoleic acid (CLA) supplements on haemoglobin levels and inflammatory markers in chronic kidney disease (CKD) patients with different haptoglobin (HP) genotypes.
This clinical trial study was conducted at Imam Khomeini Hospital, Ardabil, and Labbafinejad Hospital, Tehran, Iran, from March 2014 to March 2015, and comprised male patients with CKD and anaemia. Anthropometric factors were recorded and demographic data was collected using general questionnaires. LC (1 g/day) and CLA (2.4 g/day) supplements were given to the patients for a month. Blood samples were taken to measure haematological and inflammatory markers at the beginning and end of the study. Haptoglobin genotypes were determined using polymerase chain reaction (PCR). SPSS 21 was used for data analysis.
Among the 40 patients in the study, HP2-2 genotype was the most prevalent genotype (62.5%). The level of haemoglobin was significantly increased in the patients at the end of the study (p< 0.05). No significant changes were found in the weight, body mass index and serum levels of Interleukin-6, high-sensitivity C-reactive protein, ferritin, total iron-binding capacity and iron (p>0.05 each).
Regular diet supplementation with LC plus CLA can improve haemoglobin levels in CKD patients with anaemia.
探讨补充左旋肉碱（LC）和共轭亚油酸（CLA）对不同触珠蛋白（HP）基因型的慢性肾脏病（CKD）患者血红蛋白水平及炎症标志物的影响。
本临床试验研究于2014年3月至2015年3月在伊朗阿尔达比勒的伊玛目霍梅尼医院和德黑兰的拉巴菲内贾德医院进行，纳入患有CKD和贫血的男性患者。记录人体测量因素，并使用一般问卷收集人口统计学数据。给予患者LC（1克/天）和CLA（2.4克/天）补充剂，为期一个月。在研究开始和结束时采集血样以测量血液学和炎症标志物。使用聚合酶链反应（PCR）确定触珠蛋白基因型。采用SPSS 21进行数据分析。
在该研究的40例患者中，HP2-2基因型是最常见的基因型（62.5%）。研究结束时患者的血红蛋白水平显著升高（p<0.05）。体重、体重指数以及白细胞介素-6、高敏C反应蛋白、铁蛋白、总铁结合力和铁的血清水平均未发现显著变化（各p>0.05）。
定期在饮食中补充LC加CLA可提高患有贫血的CKD患者的血红蛋白水平。
