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源于传统锯齿状腺瘤的阑尾黏膜内癌。

Intramucosal carcinoma of the appendix arising from traditional serrated adenoma.

作者信息

Martinez Carlos Augusto Real, Cutovoi Júlia, Rossi Debora Helena, Meirelles Luciana Rodrigues, Ayrizono Maria de Lourdes Setsuko, Leal Raquel Franco, Coy Cláudio Saddy Rodrigues

机构信息

Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo, No. 126, Cidade Universitária "Zeferino Vaz", 13083-887 Campinas, SP, Brazil.

Gastrocentro, Universidade Estadual de Campinas, Rua Carlos Chagas, No. 420, Cidade Universitária "Zeferino Vaz", 13083-878 Campinas, SP, Brazil.

出版信息

Case Rep Surg. 2015;2015:297450. doi: 10.1155/2015/297450. Epub 2015 Apr 22.

DOI:10.1155/2015/297450
PMID:25977829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4421026/
Abstract

Introduction. Serrated adenomas of the appendix are rare and usually found during appendectomy or autopsies. The preoperative diagnosis of these tumors is uncommon. This report describes a case of a sessile serrated adenoma located in the appendix diagnosed by a screening colonoscopy and successfully treated by laparoscopic removal. Presentation of Case. An 86-year-old woman underwent colonoscopy to investigate the cause of her diarrhea, weight loss, and anemia. During the colonoscopy, an expansive and vegetating mass of 1.5 cm in diameter was identified, protruding through the appendicular ostium with slightly lateral growth to the cecum. The patient was referred for laparoscopic surgical resection due to the location of the lesion, which did not allow its removal by colonoscopy. She underwent wedge removal of the cecum without complications and was discharged on the 4th postoperative day. Histopathological examination showed the presence of a sessile serrated adenoma with an intramucosal adenocarcinoma. The patient is currently well one year after surgery, without endoscopic signs of relapse. Conclusion. Despite serrated adenomas being a possibility rarely described in appendix it should be recognized and properly treated because it is presenting a higher risk of cancer.

摘要

引言。阑尾锯齿状腺瘤罕见,通常在阑尾切除术或尸检时发现。这些肿瘤的术前诊断并不常见。本报告描述了一例通过筛查结肠镜诊断出位于阑尾的无蒂锯齿状腺瘤,并经腹腔镜切除成功治疗的病例。病例介绍。一名86岁女性接受结肠镜检查以探究其腹泻、体重减轻和贫血的原因。结肠镜检查期间,发现一个直径1.5厘米的扩展性、赘生性肿物,从阑尾开口处突出,向盲肠略有侧向生长。由于病变位置无法通过结肠镜切除,该患者被转诊接受腹腔镜手术切除。她接受了盲肠楔形切除术,无并发症发生,并于术后第4天出院。组织病理学检查显示存在无蒂锯齿状腺瘤伴黏膜内腺癌。该患者术后一年情况良好,无内镜下复发迹象。结论。尽管阑尾锯齿状腺瘤很少被描述,但因其具有较高的癌症风险,应予以认识并妥善治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/4421026/14bdedd65c7d/CRIS2015-297450.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/4421026/b0229a40ddf4/CRIS2015-297450.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/4421026/e4491b4ae8b5/CRIS2015-297450.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/4421026/14bdedd65c7d/CRIS2015-297450.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/4421026/b0229a40ddf4/CRIS2015-297450.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/4421026/e4491b4ae8b5/CRIS2015-297450.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/4421026/14bdedd65c7d/CRIS2015-297450.003.jpg

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本文引用的文献

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Pathogenesis and management of serrated polyps: current status and future directions.锯齿状息肉的发病机制与管理:现状与未来方向
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Serrated lesions of the appendix: do they differ from their colorectal counterparts?阑尾的锯齿状病变:它们与结直肠的同类病变有差异吗?
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Serrated lesions of the appendix frequently harbor KRAS mutations and not BRAF mutations indicating a distinctly different serrated neoplastic pathway in the appendix.
阑尾锯齿状病变常存在 KRAS 突变而不存在 BRAF 突变,提示阑尾锯齿状肿瘤途径明显不同。
Hum Pathol. 2014 Feb;45(2):227-35. doi: 10.1016/j.humpath.2013.10.021. Epub 2013 Oct 30.
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High-level microsatellite instability in appendiceal carcinomas.阑尾腺癌中高水平微卫星不稳定。
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Mucinous adenocarcinoma arising from diffuse serrated adenoma of the appendix which mimics appendicular abscess.起源于阑尾弥漫性锯齿状腺瘤的黏液腺癌,形似阑尾脓肿。
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World J Gastroenterol. 2012 Aug 28;18(32):4308-16. doi: 10.3748/wjg.v18.i32.4308.
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