Napolitano Maddalena, Megna Matteo, Monfrecola Giuseppe
Section of Dermatology, Department of Medicina Clinica e Chirurgia, University Federico II, Napoli, Italy.
ScientificWorldJournal. 2015;2015:479354. doi: 10.1155/2015/479354. Epub 2015 Apr 21.
In medical practice, almost every clinician may encounter patients with skin disease. However, it is not always easy for physicians of all specialties to face the daily task of determining the nature and clinical implication of dermatologic manifestations. Are they confined to the skin, representing a pure dermatologic event? Or are they also markers of internal conditions relating to the patient's overall health? In this review, we will discuss the principal cutaneous conditions which have been linked to metabolic alterations. Particularly, since insulin has an important role in homeostasis and physiology of the skin, we will focus on the relationships between insulin resistance (IR) and skin diseases, analyzing strongly IR-associated conditions such as acanthosis nigricans, acne, and psoriasis, without neglecting emerging and potential scenarios as the ones represented by hidradenitis suppurativa, androgenetic alopecia, and hirsutism.
在医学实践中，几乎每位临床医生都会遇到皮肤病患者。然而，对于各个专科的医生而言，面对确定皮肤表现的性质及其临床意义这一日常任务并非总是易事。这些表现是局限于皮肤，代表单纯的皮肤科事件？还是它们也是与患者整体健康相关的内部状况的标志？在本综述中，我们将讨论与代谢改变相关的主要皮肤病症。特别是，由于胰岛素在皮肤的稳态和生理学中具有重要作用，我们将重点关注胰岛素抵抗（IR）与皮肤病之间的关系，分析与IR密切相关的病症，如黑棘皮病、痤疮和银屑病，同时也不会忽视以化脓性汗腺炎、雄激素性脱发和多毛症为代表的新出现的和潜在的情况。
