铜（I）催化的带有末端烯烃部分的卤代烷烃的碳-卤键选择性硼基取代反应。

Copper(I)-catalyzed carbon-halogen bond-selective boryl substitution of alkyl halides bearing terminal alkene moieties.

作者信息

Iwamoto Hiroaki, Kubota Koji, Yamamoto Eiji, Ito Hajime

机构信息

Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628, Japan.

出版信息

Chem Commun (Camb). 2015 Jun 14;51(47):9655-8. doi: 10.1039/c5cc02760h.

DOI:10.1039/c5cc02760h

PMID:25977952

Abstract

The selective boryl substitution of alkyl halides bearing terminal C[double bond, length as m-dash]C double bonds has been achieved using a copper(i)/tricyclohexylphosphine or copper(i)/o-diphenylphosphinophenol catalyst. This reaction represents a useful complementary approach to conventional procedures for the hydroboration of C[double bond, length as m-dash]C double bonds or the borylative cyclization of alkyl halides bearing terminal alkenes.

摘要

使用铜（I）/三环己基膦或铜（I）/邻二苯基膦基苯酚催化剂，实现了对带有末端碳碳双键的卤代烃进行选择性硼基取代反应。该反应是对传统的碳碳双键硼氢化反应或带有末端烯烃的卤代烃硼基环化反应方法的一种有用的补充方法。