铜催化未活化烯烃与卤代烃的区域选择性硼羰基化偶联反应：β-硼基酮的合成
Copper-Catalyzed Regioselective Borocarbonylative Coupling of Unactivated Alkenes with Alkyl Halides: Synthesis of β-Boryl Ketones.
作者信息
Wu Fu-Peng, Yuan Yang, Schünemann Claas, Kamer Paul C J, Wu Xiao-Feng
机构信息
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, 310018, P. R. China.
出版信息
Angew Chem Int Ed Engl. 2020 Jun 22;59(26):10451-10455. doi: 10.1002/anie.202002714. Epub 2020 Apr 28.
The borocarbonylative coupling of unactivated alkenes with alkyl halides remains a challenge. In this communication, a Cu-catalyzed borocarbonylative coupling of unactivated alkenes with alkyl halides for the synthesis of β-boryl ketones has been developed. A broad range of β-boryl ketone derivatives was prepared in moderate to excellent yields with complete regioselectivity.
未活化烯烃与卤代烃的硼羰基化偶联仍然是一个挑战。在本论文中，已开发出一种铜催化的未活化烯烃与卤代烃的硼羰基化偶联反应，用于合成β-硼基酮。制备了一系列β-硼基酮衍生物，产率中等至优异，区域选择性完全。
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