Kotloff Robert M, Blosser Sandralee, Fulda Gerard J, Malinoski Darren, Ahya Vivek N, Angel Luis, Byrnes Matthew C, DeVita Michael A, Grissom Thomas E, Halpern Scott D, Nakagawa Thomas A, Stock Peter G, Sudan Debra L, Wood Kenneth E, Anillo Sergio J, Bleck Thomas P, Eidbo Elling E, Fowler Richard A, Glazier Alexandra K, Gries Cynthia, Hasz Richard, Herr Dan, Khan Akhtar, Landsberg David, Lebovitz Daniel J, Levine Deborah Jo, Mathur Mudit, Naik Priyumvada, Niemann Claus U, Nunley David R, O'Connor Kevin J, Pelletier Shawn J, Rahman Omar, Ranjan Dinesh, Salim Ali, Sawyer Robert G, Shafer Teresa, Sonneti David, Spiro Peter, Valapour Maryam, Vikraman-Sushama Deepak, Whelan Timothy P M
1Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH. 2Division of Pulmonary, Allergy, and Critical Care Medicine, Penn State Hershey Medical Center, Hershey, PA, and Pittsburgh Critical Care Associates, Pittsburgh, PA. 3Department of Surgery, Christiana Care Health System, Newark, DE. 4Department of Surgery, Portland Veterans Affairs Medical Center, Portland, OR. 5Pulmonary, Allergy, and Critical Care Division, Hospital of the University of Pennsylvania, Philadelphia, PA. 6Division of Pulmonary Diseases and Critical Care Medicine, University of Texas Health Center at San Antonio, San Antonio, TX. 7Department of Surgery, University of Minnesota Medical Center, Minneapolis, MN. 8General Surgery Department, Harlem Hospital Center, New York, NY. 9Department of Anesthesiology, University of Maryland Medical Center, Baltimore, MD. 10Section of Pediatric Critical Care, Wake Forest Baptist Health Medical Center, Winston-Salem, NC. 11Department of Surgery, University of California, San Francisco, San Francisco, CA. 12Department of Surgery, Duke University Medical Center, Durham, NC. 13Geisinger Medical Center, Danville, PA. 14SUNY Buffalo, Buffalo, NY. 15Department of Neurology, Rush Medical College, Chicago, IL. 16Association of Organ Procurement Organizations, Vienna, VA. 17New England Organ Bank, Waltham, MA. 18Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA. 19Gift of Life, Philadelphia, PA. 20Department of Medicine, University of Maryland Medical Center, Baltimore, MD. 21Department of Surgery, Alleghany General Hospital, Pittsburgh, PA. 22Department of Emergency Medicine, SUNY Upstate Medical Center, Syracuse, NY. 23Department of Pediatric Critical Care Medicine, Akron Children's Hospital, Akron, OH. 24Department of Critical Care Medicine, Loma Linda University Children's Hospital, Loma Linda, CA. 25Intensivist, Atlanta, GA. 26Division of Pulmonary and Critical Care Medicine, University o
Crit Care Med. 2015 Jun;43(6):1291-325. doi: 10.1097/CCM.0000000000000958.
This document was developed through the collaborative efforts of the Society of Critical Care Medicine, the American College of Chest Physicians, and the Association of Organ Procurement Organizations. Under the auspices of these societies, a multidisciplinary, multi-institutional task force was convened, incorporating expertise in critical care medicine, organ donor management, and transplantation. Members of the task force were divided into 13 subcommittees, each focused on one of the following general or organ-specific areas: death determination using neurologic criteria, donation after circulatory death determination, authorization process, general contraindications to donation, hemodynamic management, endocrine dysfunction and hormone replacement therapy, pediatric donor management, cardiac donation, lung donation, liver donation, kidney donation, small bowel donation, and pancreas donation. Subcommittees were charged with generating a series of management-related questions related to their topic. For each question, subcommittees provided a summary of relevant literature and specific recommendations. The specific recommendations were approved by all members of the task force and then assembled into a complete document. Because the available literature was overwhelmingly comprised of observational studies and case series, representing low-quality evidence, a decision was made that the document would assume the form of a consensus statement rather than a formally graded guideline. The goal of this document is to provide critical care practitioners with essential information and practical recommendations related to management of the potential organ donor, based on the available literature and expert consensus.
本文件是由危重病医学学会、美国胸科医师学会和器官获取组织协会共同协作完成的。在这些学会的支持下,召集了一个多学科、多机构的特别工作组,其成员涵盖了危重病医学、器官捐献者管理和移植领域的专业知识。特别工作组成员被分成13个小组委员会,每个小组委员会专注于以下一般或特定器官领域之一:使用神经学标准判定死亡、循环性死亡判定后的捐献、授权程序、捐献的一般禁忌证、血流动力学管理、内分泌功能障碍和激素替代疗法、儿科捐献者管理、心脏捐献、肺脏捐献、肝脏捐献、肾脏捐献、小肠捐献和胰腺捐献。各小组委员会负责提出一系列与其主题相关的管理问题。对于每个问题,小组委员会提供了相关文献的总结和具体建议。这些具体建议经特别工作组成员全体批准后,汇编成一份完整的文件。由于现有文献绝大多数是观察性研究和病例系列,代表低质量证据,因此决定该文件将采用共识声明的形式,而不是正式分级指南。本文件的目的是根据现有文献和专家共识,为危重病从业者提供与潜在器官捐献者管理相关的基本信息和实用建议。