Huang Xiao-Ying, Feng Zi-Ming, Yang Ya-Nan, Jiang Jian-Shuang, Zhang Pei-Cheng
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Peking Union Medical College and Institute of Materia Medica, Chinese Academy of Medical Sciences , Beijing 100050 , China.
J Asian Nat Prod Res. 2015 May;17(5):504-11. doi: 10.1080/10286020.2015.1039525. Epub 2015 May 15.
Four new neolignan glucosides named (7S, 8R)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8-O-4'-neolignan-9'-O-β-d-apiofuranosyl-(1 → 6)-O-β-d-glucopyranoside (1), (8R)-4,9,9'-trihydroxy-3,3'-dimethoxy-7-oxo-8-O-4'-neolignan-4-O-β-d-glucopyranoside (2), (7R, 8S)-dihydrodehydrodiconiferyl alcohol-7'-oxo-4-O-β-d-glucopyranoside (3), and (7'S, 8'R, 8S)-4,4',9'-trihydroxy-3,3'-dimethoxy-7',9-epoxylignan-7-oxo-4-O-β-d-glucopyranoside (4) were isolated from the fruits of Arctium lappa L. Their structures and absolute configurations were elucidated on the basis of comprehensive spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with known analogues in the literature.
从牛蒡果实中分离出四种新的木脂素苷，分别命名为(7S, 8R)-4,7,9,9'-四羟基-3,3'-二甲氧基-8-O-4'-新木脂素-9'-O-β-D-芹菜呋喃糖基-(1→6)-O-β-D-吡喃葡萄糖苷(1)、(8R)-4,9,9'-三羟基-3,3'-二甲氧基-7-氧代-8-O-4'-新木脂素-4-O-β-D-吡喃葡萄糖苷(2)、(7R, 8S)-二氢脱氢二松柏醇-7'-氧代-4-O-β-D-吡喃葡萄糖苷(3)和(7'S, 8'R, 8S)-4,4',9'-三羟基-3,3'-二甲氧基-7',9-环氧木脂素-7-氧代-4-O-β-D-吡喃葡萄糖苷(4)。基于综合光谱分析(紫外、红外、高分辨电喷雾电离质谱、一维和二维核磁共振、圆二色)以及与文献中已知类似物的比较，阐明了它们的结构和绝对构型。
