Yang Yanan, An Yawen, Wang Wei, Du Ning, Zhang Jinghua, Feng Ziming, Jiang Jianshuang, Zhang Peicheng
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Beijing Centre for Physical and Chemical Analysis, Beijing 100089, China.
Acta Pharm Sin B. 2017 Jul;7(4):491-495. doi: 10.1016/j.apsb.2017.04.004. Epub 2017 May 3.
Two new compounds, named lyciumlignan D () and lyciumphenyl propanoid A (), along with seven known compounds, were isolated from the root bark of . Their structures were elucidated using spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds - were isolated from this genus for the first time. In the assay, compounds , , and exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.
从枸杞根皮中分离出两种新化合物，分别命名为枸杞木脂素D（）和枸杞苯丙烷A（），以及七种已知化合物。通过光谱数据（紫外光谱、红外光谱、高分辨电喷雾电离质谱、一维和二维核磁共振谱、圆二色光谱）以及与文献报道的结构进行比较，阐明了它们的结构。化合物 - 首次从该属植物中分离得到。在 实验中，化合物 、 和 在浓度为10 μmol/L时表现出比阳性对照姜黄素更强的抗炎作用。
