自由活动大鼠局部脑葡萄糖利用的昼夜变化。

Circadian variations in local cerebral glucose utilization in freely moving rats.

作者信息

Room P, Tielemans A J

机构信息

Department of CNS Pharmacology, Organon International B.V., Oss, The Netherlands.

出版信息

Brain Res. 1989 Dec 29;505(2):321-5. doi: 10.1016/0006-8993(89)91460-1.

DOI:10.1016/0006-8993(89)91460-1

PMID:2598050

Abstract

Sokoloff's [14C]2-deoxyglucose method has been applied to investigate circadian variations in local cerebral glucose utilization (LCGU). Freely moving rats were tested during two phases of the circadian light/dark cycle. In the rats tested during darkness, elevations in LCGU, when compared with animals tested during the light period, were observed in the primary and secondary visual cortex, the primary auditory cortex, the lateral geniculate nucleus, the amygdala, the entorhinal cortex, the hippocampus, the substantia nigra and the cerebellum. A reduction in LCGU was observed in the suprachiasmatic nucleus.

摘要

索科洛夫的[14C]2-脱氧葡萄糖法已被用于研究局部脑葡萄糖利用（LCGU）的昼夜变化。在昼夜明暗周期的两个阶段对自由活动的大鼠进行了测试。在黑暗中测试的大鼠中，与在光照期测试的动物相比，在初级和次级视觉皮层、初级听觉皮层、外侧膝状体核、杏仁核、内嗅皮层、海马体、黑质和小脑中观察到LCGU升高。在视交叉上核中观察到LCGU降低。