Margină Denisa, Ilie Mihaela, Grădinaru Daniela, Androutsopoulos Vasilis P, Kouretas Demetrios, Tsatsakis Aristidis M
Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia St., 020956 Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia St., 020956 Bucharest, Romania.
Toxicol Lett. 2015 Aug 5;236(3):154-67. doi: 10.1016/j.toxlet.2015.05.009. Epub 2015 May 14.
A trend in the general population has been observed in recent years regarding the orientation toward preventive measures in health; in this context the increased interest from the users and researchers concerning the active effect of food supplements on the health state and on longevity, is noticeable. All over the world, the consumption of natural foods and of vegetal supplements has increased spectacularly over the last 5-10 years. The decreased prevalence of cardio-vascular diseases associated with Mediterranean diet, as well as the French paradox convinced researchers to scientifically document the beneficial outcomes pointed out by traditional use of plants, and to try to develop supplements that would have the same positive effects as these noticed for diet components. The intense research dedicated to this topic revealed the fact that food supplements are linked to some problematic aspects, such as toxicological side effects when associated with classical synthetic drugs. The food supplement-drug interactions are submitted to complex issues regarding pharmacokinetic interactions leading to changes in absorption, distribution, metabolism and excretion processes with direct impact on effect and toxicological potential. The present review based on recent literature aims at discussing the food-drug interactions with direct impact on efficacy and toxicity of drugs.
近年来，普通人群中出现了一种关注健康预防措施的趋势；在这种背景下，用户和研究人员对食品补充剂对健康状况和长寿的积极作用的兴趣日益增加，这一点很明显。在过去5至10年里，世界各地天然食品和植物补充剂的消费量大幅增加。与地中海饮食相关的心血管疾病患病率下降，以及法国悖论，促使研究人员科学地记录传统植物使用所指出的有益结果，并试图开发出与饮食成分具有相同积极效果的补充剂。针对这一主题的深入研究揭示了这样一个事实，即食品补充剂与一些问题相关，比如与传统合成药物联用时的毒理学副作用。食品补充剂与药物的相互作用存在一些复杂问题，涉及药代动力学相互作用，会导致吸收、分布、代谢和排泄过程发生变化，直接影响药物疗效和毒理学潜力。本综述基于近期文献，旨在探讨对药物疗效和毒性有直接影响的食品与药物相互作用。
