Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China.
Division of Cardiology, Cardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.
Arch Med Res. 2015 Apr;46(3):199-206. doi: 10.1016/j.arcmed.2015.03.011. Epub 2015 May 14.
Current evidence suggests that a high neutrophil/lymphocyte ratio (NLR) may increase the risk of atrial fibrillation (AF), but this association is still uncertain. The aim of the comprehensive meta-analysis was to evaluate the potential association between NLR and the risk of AF.
We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase, Cochrane Database and Web of Science) to identify the studies reporting the association between NLR and risk of AF. We searched the literature published January 2015 or earlier. We used both fixed-effects and random-effects models to calculate the overall effect estimate. An I(2) > 50% indicates at least moderate statistical heterogeneity. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity.
We retrieved 11 studies involving a total of 2,766 participants. The combined odds ratio (OR) of incident AF for baseline NLR level was 1.25 (95% confidence interval [CI] 1.16-1.35) with significant heterogeneity across studies (I(2) = 82.7%, p < 0.01) and for the post-NLR level (following CABG, RFCA and cardioversion) was 1.518 (95% CI 1.076-2.142) with significant heterogeneity across studies (I(2) = 93.7%, p = 0.017). We also showed an association between AF recurrence following CABG, RFCA and cardioversion and baseline NLR level (OR 1.517, 95% CI 1.108-2.079) with significant heterogeneity across studies (I(2) = 86.8%, p < 0.01).
Our comprehensive meta-analysis suggests that the high level of NLR, whether baseline or postsurgery/procedure, is associated with the increased risk of AF recurrence/occurrence.
目前的证据表明，高中性粒细胞/淋巴细胞比值（NLR）可能会增加心房颤动（AF）的风险，但这种关联尚不确定。本次全面荟萃分析的目的是评估 NLR 与 AF 风险之间的潜在关联。
我们使用电子数据库（PubMed、Ovid、Embase、Cochrane 数据库和 Web of Science）进行了系统的文献检索，以确定报告 NLR 与 AF 风险之间关联的研究。我们检索了 2015 年 1 月或更早发表的文献。我们使用固定效应和随机效应模型来计算总体效应估计。I(2)>50%表示存在至少中等程度的统计学异质性。我们进行了敏感性分析和亚组分析，以确定异质性的来源。
我们检索到了 11 项研究，共涉及 2766 名参与者。基线 NLR 水平与新发 AF 的合并比值比（OR）为 1.25（95%置信区间[CI] 1.16-1.35），研究之间存在显著的异质性（I(2)=82.7%，p<0.01）；术后 NLR 水平（CABG、RFCA 和电复律后）与新发 AF 的合并 OR 为 1.518（95%CI 1.076-2.142），研究之间存在显著的异质性（I(2)=93.7%，p=0.017）。我们还发现 CABG、RFCA 和电复律后 AF 复发与基线 NLR 水平之间存在关联（OR 1.517，95%CI 1.108-2.079），研究之间存在显著的异质性（I(2)=86.8%，p<0.01）。
我们的全面荟萃分析表明，无论是基线还是手术后/手术后 NLR 水平升高与 AF 复发/发生的风险增加相关。
