Bartůnková J, Fucíková T, Sulková S, Marecková H
Cas Lek Cesk. 1989 Oct 13;128(42):1332-5.
The authors investigated the influence exerted on some lymphocyte and granulocyte functions during treatment with human recombinant erythropoietin in five female patients with renal failure due to chronic interstitial nephritis, who were included in a regular dialyzation programme. The authors revealed a significant increase of the candidacidal capacity of phagocytizing cells of the peripheral blood stream and an increased capacity of blastic transformation of lymphocytes after stimulation with the mitogen phytohaemagglutinin. In these changes the improved oxygen metabolism may participate by a correction of anaemia, when this preparation is administered, but it cannot be ruled out that erythropoietin interferes by some hitherto unknown mechanism with immune processes.
作者对五名因慢性间质性肾炎导致肾衰竭并纳入常规透析计划的女性患者，在使用重组人促红细胞生成素治疗期间，对某些淋巴细胞和粒细胞功能所产生的影响进行了研究。作者发现，外周血流中吞噬细胞的杀念珠菌能力显著增强，并且在用丝裂原植物血凝素刺激后，淋巴细胞的原始转化能力有所提高。在这些变化中，当使用这种制剂时，改善的氧代谢可能通过纠正贫血而发挥作用，但不能排除促红细胞生成素通过某种迄今未知的机制干扰免疫过程。
