Kalita Z, Gatková A, Gregorová A, Adamíková A
Cas Lek Cesk. 1989 Oct 27;128(43-44):1353-6.
In 1987-1988 the authors subjected to comprehensive neurological examination 79 type I diabetics. The group comprised subjects under 60 years and patients with other possible neurotoxic influences were eliminated. After a detailed clinical examination in 75.9% diabetics clinical signs of affection of the peripheral nervous system were revealed, incl. 45.6% clinical diabetic neuropathies were detected. In all instances it was symmetrical distal sensory or sensomotor polyneuropathy and in four instances moreover the carpal tunnel syndrome was detected. The most frequent neurological disorder was panhypaesthesia on the acra of the lower extremities. The most frequent subjective complaint were paraesthesias of the feet and subsequent cramps. The authors investigated moreover parameters of the long-term compensation of diabetes, the duration of diabetes and the biological age of diabetics. They assessed the statistical significance of these parameters for the development of diabetic neuropathy which was proved only for the parameter of the duration of the disease and the biological age of type I diabetics (p less than 0.05).
1987年至1988年，作者对79例I型糖尿病患者进行了全面的神经学检查。该组包括60岁以下的受试者，排除了有其他可能神经毒性影响的患者。经过详细的临床检查，75.9%的糖尿病患者出现了周围神经系统受累的临床体征，其中45.6%检测出临床糖尿病神经病变。在所有病例中均为对称性远端感觉或感觉运动性多发性神经病，此外有4例检测出腕管综合征。最常见的神经障碍是下肢末端全感觉减退。最常见的主观症状是足部感觉异常及随后的痉挛。作者还研究了糖尿病长期代偿参数、糖尿病病程及糖尿病患者的生物学年龄。他们评估了这些参数对糖尿病神经病变发生发展的统计学意义，结果仅证实病程参数和I型糖尿病患者的生物学年龄具有统计学意义（p<0.05）。
