Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL, USA.
Curr Atheroscler Rep. 2015 Jul;17(7):36. doi: 10.1007/s11883-015-0517-6.
The 2-year risk of ipsilateral ischemic stroke following internal carotid artery occlusion (ICAO) in a patient undergoing maximal medical therapy is 5-8% per year. While medical therapy may reduce the risk of stroke, it does not completely eliminate it. Since the 1985 extracranial-intracranial (EC-IC) bypass study, additional trials have been conducted to further investigate the usefulness of EC-IC bypass surgery in more selected patients with cerebral ischemia and impaired hemodynamic reserve. These important studies will be briefly reviewed in this article, as well as a discussion regarding the utility of bypass surgery for ICAO in current clinical practice. In addition, a short discussion regarding the pathophysiology of carotid occlusion will be presented. We will also highlight our own institutional patient selection criteria based on the latest methods for hemodynamic assessment, as well as our intraoperative flow assisted surgical techniques (FAST), and post-operative patient follow-up.
在接受最大药物治疗的患者中,颈内动脉闭塞(ICAO)后同侧缺血性卒中的 2 年风险为每年 5-8%。虽然药物治疗可能会降低卒中风险,但并不能完全消除。自 1985 年颅外-颅内(EC-IC)旁路研究以来,已经进行了更多的试验,以进一步研究在更多有脑缺血和血液动力学储备受损的选择性患者中进行 EC-IC 旁路手术的有用性。本文将简要回顾这些重要的研究,并讨论目前临床实践中 ICAO 旁路手术的实用性。此外,还将讨论颈动脉闭塞的病理生理学。我们还将根据最新的血液动力学评估方法,以及我们的术中血流辅助手术技术(FAST)和术后患者随访,重点介绍我们机构的患者选择标准。