雷诺嗪可显著提高他克莫司的血药浓度。
Ranolazine can markedly increase tacrolimus blood levels.
作者信息
Seck Sidy, Bellantoni Marianna, Zoccali Carmine, Enia Giuseppe
机构信息
Nephrology Department , University Hospital Aristide Le Dantec , Dakar Senegal ; Nephrology, Hypertension and Renal Transplantation Unit, CNR-IBIM Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension , Ospedali Riuniti , Reggio Calabria, Italy.
Nephrology, Hypertension and Renal Transplantation Unit, CNR-IBIM Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension , Ospedali Riuniti , Reggio Calabria, Italy.
出版信息
NDT Plus. 2011 Feb;4(1):44-5. doi: 10.1093/ndtplus/sfq180. Epub 2010 Oct 25.
We report the case of a renal transplant patient on tacrolimus who developed a fully reversible renal failure and a doubling in serum tacrolimus closely associated with initiation of ranolazine (Ranexa) treatment, a new anti-angina drug recently introduced in Europe.
我们报告了一例接受他克莫司治疗的肾移植患者，该患者出现了完全可逆性肾衰竭，且血清他克莫司浓度翻倍，这与雷诺嗪（Ranexa）治疗的开始密切相关，雷诺嗪是一种最近在欧洲推出的新型抗心绞痛药物。
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