Kiszewska Natalia, Bień Ewa, Irga-Jaworska Ninela, Adamkiewicz-Drożyńska Elżbieta
Biomark Med. 2015;9(5):461-71. doi: 10.2217/bmm.14.101.
Infections in children treated for hematological malignancies pose a direct threat to life and are one of the most common causes of treatment failure in this group of patients. Unequivocal diagnosis at the early stages of infection together with an appropriate and timely treatment may be often difficult due to poor manifestation and nonspecific clinical symptoms of the infection progress. Inflammatory markers make a useful diagnostic tool for this purpose. They significantly help to diagnose, monitor, stratify and predict the outcome in severe infections. This article describes selected biomarkers, both those commonly used in clinical practice, such as erythrocyte sedimentation rate, C-reactive protein, procalcitonin as well as less common like IL-6, IL-8 and moreover one promising novel marker - pentraxin 3. The authors emphasize their diagnostic value, clinical usefulness and significance in the treatment efficacy monitoring.
接受血液系统恶性肿瘤治疗的儿童感染对生命构成直接威胁，是这类患者治疗失败的最常见原因之一。由于感染进展的表现不佳和临床症状不具特异性，在感染早期进行明确诊断并同时进行适当和及时的治疗往往很困难。炎症标志物为此提供了一种有用的诊断工具。它们在严重感染的诊断、监测、分层和预后预测方面有显著帮助。本文介绍了一些选定的生物标志物，包括临床实践中常用的，如红细胞沉降率、C反应蛋白、降钙素原，以及不太常用的如白细胞介素-6、白细胞介素-8，此外还有一种有前景的新型标志物——五聚素3。作者强调了它们的诊断价值、临床实用性以及在治疗效果监测中的意义。
