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本文引用的文献

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Persistence of Klebsiella pneumoniae ST258 as the predominant clone of carbapenemase-producing Enterobacteriaceae in post-acute-care hospitals in Israel, 2008-13.2008-2013 年，在以色列的急性后期护理医院中，肺炎克雷伯菌 ST258 作为产碳青霉烯酶肠杆菌科的主要克隆持续存在。
J Antimicrob Chemother. 2015 Jan;70(1):89-92. doi: 10.1093/jac/dku333. Epub 2014 Sep 8.
2
Development and validation of a multiplex PCR assay for identification of the epidemic ST-258/512 KPC-producing Klebsiella pneumoniae clone.建立并验证一种多重 PCR 方法用于鉴定流行的产 KPC 肺炎克雷伯菌 ST-258/512 克隆。
Diagn Microbiol Infect Dis. 2014 Jan;78(1):12-5. doi: 10.1016/j.diagmicrobio.2013.10.003. Epub 2013 Oct 14.
3
Mutations of the ompK36 porin gene and promoter impact responses of sequence type 258, KPC-2-producing Klebsiella pneumoniae strains to doripenem and doripenem-colistin.ompK36 孔蛋白基因和启动子突变影响携带 KPC-2 基因的 258 型肺炎克雷伯菌对多利培南和多利培南-黏菌素的反应。
Antimicrob Agents Chemother. 2013 Nov;57(11):5258-65. doi: 10.1128/AAC.01069-13. Epub 2013 Aug 12.
4
Epidemiological and microbiological characteristics of an outbreak caused by OXA-48-producing Enterobacteriaceae in a neonatal intensive care unit in Jerusalem, Israel.以色列耶路撒冷一家新生儿重症监护病房中产 OXA-48 型肠杆菌科细菌暴发的流行病学和微生物学特征。
J Clin Microbiol. 2013 Sep;51(9):2926-30. doi: 10.1128/JCM.01049-13. Epub 2013 Jun 26.
5
Rapid identification of carbapenemase types in Enterobacteriaceae and Pseudomonas spp. by using a biochemical test.采用生化试验快速鉴定肠杆菌科和铜绿假单胞菌的碳青霉烯酶类型。
Antimicrob Agents Chemother. 2012 Dec;56(12):6437-40. doi: 10.1128/AAC.01395-12. Epub 2012 Oct 15.
6
Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions.肺炎克雷伯菌和其他肠杆菌科细菌中的碳青霉烯酶：具有全球范围的不断演变的危机。
Clin Microbiol Rev. 2012 Oct;25(4):682-707. doi: 10.1128/CMR.05035-11.
7
A swordless knight: epidemiology and molecular characteristics of the blaKPC-negative sequence type 258 Klebsiella pneumoniae clone.无剑骑士：blaKPC 阴性序列型 258 肺炎克雷伯菌克隆的流行病学和分子特征。
J Clin Microbiol. 2012 Oct;50(10):3180-5. doi: 10.1128/JCM.00987-12. Epub 2012 Jul 18.
8
Porin alterations present in non-carbapenemase-producing Enterobacteriaceae with high and intermediate levels of carbapenem resistance in Chile.智利高和中度碳青霉烯类耐药非产碳青霉烯酶肠杆菌科细菌中存在孔蛋白改变。
J Med Microbiol. 2012 Sep;61(Pt 9):1270-1279. doi: 10.1099/jmm.0.045799-0. Epub 2012 Jun 14.
9
Rapid detection of carbapenemase genes by multiplex real-time PCR.多重实时 PCR 快速检测碳青霉烯酶基因。
J Antimicrob Chemother. 2012 Apr;67(4):906-9. doi: 10.1093/jac/dkr563. Epub 2012 Jan 9.
10
Genetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae.与产 KPC 肺炎克雷伯菌碳青霉烯类耐药升高相关的遗传因素。
Antimicrob Agents Chemother. 2010 Oct;54(10):4201-7. doi: 10.1128/AAC.00008-10. Epub 2010 Jul 26.

具有边缘型碳青霉烯类耐药的肺炎克雷伯菌分离株的耐药机制对碳青霉烯类药物接种物效应的影响。

Effect of Resistance Mechanisms on the Inoculum Effect of Carbapenem in Klebsiella pneumoniae Isolates with Borderline Carbapenem Resistance.

机构信息

National Center for Infection Control, Ministry of Health, Tel Aviv, Israel; Section of Epidemiology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel

National Center for Infection Control, Ministry of Health, Tel Aviv, Israel; Section of Epidemiology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.

出版信息

Antimicrob Agents Chemother. 2015 Aug;59(8):5014-7. doi: 10.1128/AAC.00533-15. Epub 2015 May 18.

DOI:10.1128/AAC.00533-15
PMID:25987630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4505287/
Abstract

We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolates exhibited a marked inoculum effect and were more resistant to the bactericidal effect of meropenem. This suggests that MIC measurements alone may not be sufficient in predicting the therapeutic efficacy of carbapenems against CPKP.

摘要

我们旨在研究耐药机制对几种碳青霉烯类药物中介耐碳青霉烯类肺炎克雷伯菌分离株耐药表型的影响。我们比较了碳青霉烯酶阴性肺炎克雷伯菌和碳青霉烯酶产生肺炎克雷伯菌（CPKP）分离株，它们的 MIC 相似。CPKP 分离株表现出明显的接种体效应，对美罗培南的杀菌作用更具耐药性。这表明，单独的 MIC 测量可能不足以预测碳青霉烯类药物对 CPKP 的治疗效果。