序列类型 273 碳青霉烯类耐药肺炎克雷伯菌携带 blaCTX-M-15 和.
Sequence Type 273 Carbapenem-Resistant Klebsiella pneumoniae Carrying and .
机构信息
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
出版信息
Antimicrob Agents Chemother. 2018 May 25;62(6). doi: 10.1128/AAC.00160-18. Print 2018 Jun.
Abstract
A carbapenem-resistant isolate was recovered from human blood. Its whole-genome sequence was obtained using Illumina and long-read MinION sequencing. The strain belongs to sequence type 273 (ST273), which was found recently and caused an outbreak in Southeast Asia. It has two carbapenemase genes, (carried by an ST7 IncN self-transmissible plasmid) and (located on a self-transmissible IncHI5 plasmid). Non-KPC-producing ST237 may represent a lineage of carbapenem-resistant , which warrants further monitoring.
摘要
从人体血液中分离出一株耐碳青霉烯的 。采用 Illumina 和长读长 MinION 测序技术获得其全基因组序列。该菌株属于最近发现的序列类型 273（ST273），该序列类型曾在东南亚引发过一次暴发。它携带两种碳青霉烯酶基因， （位于一个可自我传播的 ST7 IncN 质粒上）和 （位于一个可自我传播的 IncHI5 质粒上）。非产 KPC 的 ST237 可能代表了耐碳青霉烯 的一个谱系，值得进一步监测。
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